Supragastric belch may be related to globus symptom – a prospective clinical study
Background The etiology of globus is poorly understood. It is controversial, whether gastroesophageal reflux disease (GERD) has a role in globus. To investigate the possible esophageal background of this symptom, we performed transnasal esophagoscopy (TNE), high‐resolution manometry (HRM), and 24‐h...
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| Veröffentlicht in: | Neurogastroenterology and motility 2016-05, Vol.28 (5), p.680-686 |
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| creator | Nevalainen, P. Walamies, M. Kruuna, O. Arkkila, P. Aaltonen, L.‐M. |
| description | Background
The etiology of globus is poorly understood. It is controversial, whether gastroesophageal reflux disease (GERD) has a role in globus. To investigate the possible esophageal background of this symptom, we performed transnasal esophagoscopy (TNE), high‐resolution manometry (HRM), and 24‐h multichannel intraluminal impedance (MII) and pH monitoring on globus patients.
Methods
Thirty consecutive patients were referred to Helsinki University Hospital, Department of Otorhinolaryngology – Head and Neck Surgery for treatment of globus; 24 consecutive patients with difficult reflux symptoms from the Department of Surgery served as controls. We compared the results of the patient groups in endoscopies, HRM, and 24‐h MII‐pH monitoring.
Key Results
In MII monitoring, globus patients had supragastric belch (6/20, 30% vs 1/24, 4%; p = 0.038) more often than controls. Total reflux time was higher in controls (p = 0.004), and they had more acid reflux events (p = 0.002) in MII, but between groups, the number of non‐acid reflux events was similar. In pH monitoring, DeMeester score and total pH |
| doi_str_mv | 10.1111/nmo.12764 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1787976069</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4032225521</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3864-51e8159433c544a3a190b6d8d61a3cfc674b03a4f0dee79540069a10938844013</originalsourceid><addsrcrecordid>eNqN0btOwzAYBWALgWgpDLwAssQCQ1rf4sQjqrhJBQbKHDmOU1I5TbATUDbegTfkSXCbwoCEhBd7-Hz02weAY4zG2K_JqqzGmESc7YAhpjwMiIjJ7vocogALEg7AgXNLhBAnjO-DAeERY0SQIZg_trWVC-kaWyiYaqOeYSk7f4JWG9noDDYVXJgqbR10XVk3VQk_3z-ghLWtXK1VU7xqqEyxKpQ00DVt1h2CvVwap4-2-wg8XV3OpzfB7OH6dnoxCxSNOQtCrGMcCkapChmTVGKBUp7FGceSqlz5IVNEJctRpnUkQubnFxIjQeOYMYTpCJz1uX6Ul1a7JikLp7QxcqWr1iU4iiMRcX_rP5QKjCJEPT39RZdVa1f-IRvFOfHQq_NeKf8Nzuo8qW1RStslGCXrVhLfSrJpxduTbWKbljr7kd81eDDpwVthdPd3UnJ_99BHfgG5HZTe</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1783662910</pqid></control><display><type>article</type><title>Supragastric belch may be related to globus symptom – a prospective clinical study</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><source>Wiley Online Library (Open Access Collection)</source><creator>Nevalainen, P. ; Walamies, M. ; Kruuna, O. ; Arkkila, P. ; Aaltonen, L.‐M.</creator><creatorcontrib>Nevalainen, P. ; Walamies, M. ; Kruuna, O. ; Arkkila, P. ; Aaltonen, L.‐M.</creatorcontrib><description>Background
The etiology of globus is poorly understood. It is controversial, whether gastroesophageal reflux disease (GERD) has a role in globus. To investigate the possible esophageal background of this symptom, we performed transnasal esophagoscopy (TNE), high‐resolution manometry (HRM), and 24‐h multichannel intraluminal impedance (MII) and pH monitoring on globus patients.
Methods
Thirty consecutive patients were referred to Helsinki University Hospital, Department of Otorhinolaryngology – Head and Neck Surgery for treatment of globus; 24 consecutive patients with difficult reflux symptoms from the Department of Surgery served as controls. We compared the results of the patient groups in endoscopies, HRM, and 24‐h MII‐pH monitoring.
Key Results
In MII monitoring, globus patients had supragastric belch (6/20, 30% vs 1/24, 4%; p = 0.038) more often than controls. Total reflux time was higher in controls (p = 0.004), and they had more acid reflux events (p = 0.002) in MII, but between groups, the number of non‐acid reflux events was similar. In pH monitoring, DeMeester score and total pH <4 time were higher in controls (P < 0.001). In HRM, the upper esophageal sphincter (UES) mean basal and residual pressures did not differ.
Conclusions & Inferences
Supragastric belch was more common in globus patients, suggesting the possible role of this condition in globus sensation. However, globus patients in this series had no acid or non‐acid GERD or elevated UES pressure.
The aim was to investigate the possible esophageal background of globus symptoms, patients with reflux symptoms served as controls. In this study, globus patients without reflux symptoms did not have acid or non‐acid GERD in 24‐h MII‐pH monitoring. However, globus patients had supragastric belch more often than patients with reflux symptoms.</description><identifier>ISSN: 1350-1925</identifier><identifier>EISSN: 1365-2982</identifier><identifier>DOI: 10.1111/nmo.12764</identifier><identifier>PMID: 26744292</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>24‐h multichannel intraluminal impedance and pH monitoring ; Acids ; Adult ; Aged ; Eructation - diagnosis ; Eructation - physiopathology ; Esophageal pH Monitoring - methods ; Female ; Gastroesophageal reflux ; Gastroesophageal Reflux - diagnosis ; Gastroesophageal Reflux - physiopathology ; globus ; high‐resolution manometry ; Humans ; Male ; Manometry - methods ; Middle Aged ; Otolaryngology ; Prospective Studies ; supragastric belch ; transnasal esophagoscopy ; Young Adult</subject><ispartof>Neurogastroenterology and motility, 2016-05, Vol.28 (5), p.680-686</ispartof><rights>2016 John Wiley & Sons Ltd</rights><rights>2016 John Wiley & Sons Ltd.</rights><rights>Copyright © 2016 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3864-51e8159433c544a3a190b6d8d61a3cfc674b03a4f0dee79540069a10938844013</citedby><cites>FETCH-LOGICAL-c3864-51e8159433c544a3a190b6d8d61a3cfc674b03a4f0dee79540069a10938844013</cites><orcidid>0000-0003-0106-0163</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fnmo.12764$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fnmo.12764$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26744292$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nevalainen, P.</creatorcontrib><creatorcontrib>Walamies, M.</creatorcontrib><creatorcontrib>Kruuna, O.</creatorcontrib><creatorcontrib>Arkkila, P.</creatorcontrib><creatorcontrib>Aaltonen, L.‐M.</creatorcontrib><title>Supragastric belch may be related to globus symptom – a prospective clinical study</title><title>Neurogastroenterology and motility</title><addtitle>Neurogastroenterol Motil</addtitle><description>Background
The etiology of globus is poorly understood. It is controversial, whether gastroesophageal reflux disease (GERD) has a role in globus. To investigate the possible esophageal background of this symptom, we performed transnasal esophagoscopy (TNE), high‐resolution manometry (HRM), and 24‐h multichannel intraluminal impedance (MII) and pH monitoring on globus patients.
Methods
Thirty consecutive patients were referred to Helsinki University Hospital, Department of Otorhinolaryngology – Head and Neck Surgery for treatment of globus; 24 consecutive patients with difficult reflux symptoms from the Department of Surgery served as controls. We compared the results of the patient groups in endoscopies, HRM, and 24‐h MII‐pH monitoring.
Key Results
In MII monitoring, globus patients had supragastric belch (6/20, 30% vs 1/24, 4%; p = 0.038) more often than controls. Total reflux time was higher in controls (p = 0.004), and they had more acid reflux events (p = 0.002) in MII, but between groups, the number of non‐acid reflux events was similar. In pH monitoring, DeMeester score and total pH <4 time were higher in controls (P < 0.001). In HRM, the upper esophageal sphincter (UES) mean basal and residual pressures did not differ.
Conclusions & Inferences
Supragastric belch was more common in globus patients, suggesting the possible role of this condition in globus sensation. However, globus patients in this series had no acid or non‐acid GERD or elevated UES pressure.
The aim was to investigate the possible esophageal background of globus symptoms, patients with reflux symptoms served as controls. In this study, globus patients without reflux symptoms did not have acid or non‐acid GERD in 24‐h MII‐pH monitoring. However, globus patients had supragastric belch more often than patients with reflux symptoms.</description><subject>24‐h multichannel intraluminal impedance and pH monitoring</subject><subject>Acids</subject><subject>Adult</subject><subject>Aged</subject><subject>Eructation - diagnosis</subject><subject>Eructation - physiopathology</subject><subject>Esophageal pH Monitoring - methods</subject><subject>Female</subject><subject>Gastroesophageal reflux</subject><subject>Gastroesophageal Reflux - diagnosis</subject><subject>Gastroesophageal Reflux - physiopathology</subject><subject>globus</subject><subject>high‐resolution manometry</subject><subject>Humans</subject><subject>Male</subject><subject>Manometry - methods</subject><subject>Middle Aged</subject><subject>Otolaryngology</subject><subject>Prospective Studies</subject><subject>supragastric belch</subject><subject>transnasal esophagoscopy</subject><subject>Young Adult</subject><issn>1350-1925</issn><issn>1365-2982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0btOwzAYBWALgWgpDLwAssQCQ1rf4sQjqrhJBQbKHDmOU1I5TbATUDbegTfkSXCbwoCEhBd7-Hz02weAY4zG2K_JqqzGmESc7YAhpjwMiIjJ7vocogALEg7AgXNLhBAnjO-DAeERY0SQIZg_trWVC-kaWyiYaqOeYSk7f4JWG9noDDYVXJgqbR10XVk3VQk_3z-ghLWtXK1VU7xqqEyxKpQ00DVt1h2CvVwap4-2-wg8XV3OpzfB7OH6dnoxCxSNOQtCrGMcCkapChmTVGKBUp7FGceSqlz5IVNEJctRpnUkQubnFxIjQeOYMYTpCJz1uX6Ul1a7JikLp7QxcqWr1iU4iiMRcX_rP5QKjCJEPT39RZdVa1f-IRvFOfHQq_NeKf8Nzuo8qW1RStslGCXrVhLfSrJpxduTbWKbljr7kd81eDDpwVthdPd3UnJ_99BHfgG5HZTe</recordid><startdate>201605</startdate><enddate>201605</enddate><creator>Nevalainen, P.</creator><creator>Walamies, M.</creator><creator>Kruuna, O.</creator><creator>Arkkila, P.</creator><creator>Aaltonen, L.‐M.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0106-0163</orcidid></search><sort><creationdate>201605</creationdate><title>Supragastric belch may be related to globus symptom – a prospective clinical study</title><author>Nevalainen, P. ; Walamies, M. ; Kruuna, O. ; Arkkila, P. ; Aaltonen, L.‐M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3864-51e8159433c544a3a190b6d8d61a3cfc674b03a4f0dee79540069a10938844013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>24‐h multichannel intraluminal impedance and pH monitoring</topic><topic>Acids</topic><topic>Adult</topic><topic>Aged</topic><topic>Eructation - diagnosis</topic><topic>Eructation - physiopathology</topic><topic>Esophageal pH Monitoring - methods</topic><topic>Female</topic><topic>Gastroesophageal reflux</topic><topic>Gastroesophageal Reflux - diagnosis</topic><topic>Gastroesophageal Reflux - physiopathology</topic><topic>globus</topic><topic>high‐resolution manometry</topic><topic>Humans</topic><topic>Male</topic><topic>Manometry - methods</topic><topic>Middle Aged</topic><topic>Otolaryngology</topic><topic>Prospective Studies</topic><topic>supragastric belch</topic><topic>transnasal esophagoscopy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nevalainen, P.</creatorcontrib><creatorcontrib>Walamies, M.</creatorcontrib><creatorcontrib>Kruuna, O.</creatorcontrib><creatorcontrib>Arkkila, P.</creatorcontrib><creatorcontrib>Aaltonen, L.‐M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Neurogastroenterology and motility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nevalainen, P.</au><au>Walamies, M.</au><au>Kruuna, O.</au><au>Arkkila, P.</au><au>Aaltonen, L.‐M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Supragastric belch may be related to globus symptom – a prospective clinical study</atitle><jtitle>Neurogastroenterology and motility</jtitle><addtitle>Neurogastroenterol Motil</addtitle><date>2016-05</date><risdate>2016</risdate><volume>28</volume><issue>5</issue><spage>680</spage><epage>686</epage><pages>680-686</pages><issn>1350-1925</issn><eissn>1365-2982</eissn><abstract>Background
The etiology of globus is poorly understood. It is controversial, whether gastroesophageal reflux disease (GERD) has a role in globus. To investigate the possible esophageal background of this symptom, we performed transnasal esophagoscopy (TNE), high‐resolution manometry (HRM), and 24‐h multichannel intraluminal impedance (MII) and pH monitoring on globus patients.
Methods
Thirty consecutive patients were referred to Helsinki University Hospital, Department of Otorhinolaryngology – Head and Neck Surgery for treatment of globus; 24 consecutive patients with difficult reflux symptoms from the Department of Surgery served as controls. We compared the results of the patient groups in endoscopies, HRM, and 24‐h MII‐pH monitoring.
Key Results
In MII monitoring, globus patients had supragastric belch (6/20, 30% vs 1/24, 4%; p = 0.038) more often than controls. Total reflux time was higher in controls (p = 0.004), and they had more acid reflux events (p = 0.002) in MII, but between groups, the number of non‐acid reflux events was similar. In pH monitoring, DeMeester score and total pH <4 time were higher in controls (P < 0.001). In HRM, the upper esophageal sphincter (UES) mean basal and residual pressures did not differ.
Conclusions & Inferences
Supragastric belch was more common in globus patients, suggesting the possible role of this condition in globus sensation. However, globus patients in this series had no acid or non‐acid GERD or elevated UES pressure.
The aim was to investigate the possible esophageal background of globus symptoms, patients with reflux symptoms served as controls. In this study, globus patients without reflux symptoms did not have acid or non‐acid GERD in 24‐h MII‐pH monitoring. However, globus patients had supragastric belch more often than patients with reflux symptoms.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>26744292</pmid><doi>10.1111/nmo.12764</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0106-0163</orcidid></addata></record> |
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| ispartof | Neurogastroenterology and motility, 2016-05, Vol.28 (5), p.680-686 |
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| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Wiley Online Library (Open Access Collection) |
| subjects | 24‐h multichannel intraluminal impedance and pH monitoring Acids Adult Aged Eructation - diagnosis Eructation - physiopathology Esophageal pH Monitoring - methods Female Gastroesophageal reflux Gastroesophageal Reflux - diagnosis Gastroesophageal Reflux - physiopathology globus high‐resolution manometry Humans Male Manometry - methods Middle Aged Otolaryngology Prospective Studies supragastric belch transnasal esophagoscopy Young Adult |
| title | Supragastric belch may be related to globus symptom – a prospective clinical study |
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