RNA-Seq Accurately Identifies Cancer Biomarker Signatures to Distinguish Tissue of Origin

Abstract Metastatic cancer of unknown primary (CUP) accounts for up to 5% of all new cancer cases, with a 5-year survival rate of only 10%. Accurate identification of tissue of origin would allow for directed, personalized therapies to improve clinical outcomes. Our objective was to use transcriptom...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Neoplasia (New York, N.Y.) N.Y.), 2014-11, Vol.16 (11), p.918-927
Hauptverfasser:	Wei, Iris H, Shi, Yang, Jiang, Hui, Kumar-Sinha, Chandan, Chinnaiyan, Arul M
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Biomarkers, Tumor - genetics Cell Line, Tumor Female Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Humans Logistic Models Male Models, Genetic Neoplasms, Unknown Primary - genetics Neoplasms, Unknown Primary - pathology Oncology Reproducibility of Results Sequence Analysis, RNA - methods
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!