Decoding complex patterns of genomic rearrangement in hepatocellular carcinoma

Elucidating the molecular basis of hepatocellular carcinoma (HCC) is crucial to developing targeted diagnostics and therapies for this deadly disease. The landscape of somatic genomic rearrangements (GRs), which can lead to oncogenic gene fusions, remains poorly characterized in HCC. We have predict...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 2014-02, Vol.103 (2-3), p.189-203
Hauptverfasser:	Fernandez-Banet, Julio, Lee, Nikki P., Chan, Kin Tak, Gao, Huan, Liu, Xiao, Sung, Wing-Kin, Tan, Winnie, Fan, Sheung Tat, Poon, Ronnie T., Li, Shiyong, Ching, Keith, Rejto, Paul A., Mao, Mao, Kan, Zhengyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Hepatocellular - genetics Chromosomes, Human, Pair 1 - genetics Chromosomes, Human, Pair 8 - genetics Cohort Studies Copy number variation Female Gene Rearrangement Genome, Human Genome-Wide Association Study - methods Genomic rearrangement Hepatocellular carcinoma Humans Liver Neoplasms - genetics Male Translocation, Genetic Whole-genome sequencing
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