The LINA cohort: Cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy
Abstract Rationale Cord blood eosinophil/basophil progenitor cells (Eo/B) of high risk infants have been shown to predict respiratory illnesses in infancy. Here we investigated this association in a population-based cohort. Furthermore, we analysed whether newborns Th1/Th2 balance and prenatal envir...
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| Veröffentlicht in: | Clinical immunology (Orlando, Fla.) Fla.), 2014-05, Vol.152 (1), p.68-76 |
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| creator | Junge, Kristin M Hörnig, Friederike Herberth, Gunda Röder, Stefan Kohajda, Tibor Rolle-Kampczyk, Ulrike von Bergen, Martin Borte, Michael Simon, Jan-Christoph Heroux, Delia Denburg, Judah A Lehmann, Irina |
| description | Abstract Rationale Cord blood eosinophil/basophil progenitor cells (Eo/B) of high risk infants have been shown to predict respiratory illnesses in infancy. Here we investigated this association in a population-based cohort. Furthermore, we analysed whether newborns Th1/Th2 balance and prenatal environmental exposure impact Eo/B recruitment. Methods In a sub-cohort of the LINA study cord blood mononuclear cells were used for methylcellulose assays to assess Eo/B differentiation. Questionnaires were recorded during pregnancy and annually thereafter. Volatile organic compounds were measured during pregnancy and cord blood cytokines after ex vivo stimulation. Results Cord blood IL-4 and IL-13 positively correlated with Eo/B. Tobacco smoke related benzene was also positively associated with Eo/B. Enhanced Eo/B numbers increased the risk for wheezing within the first 24 months. Conclusions The association between cord blood Eo/B and respiratory illnesses is not restricted to high-risk children. Prenatal environmental exposure and a Th2 milieu at birth contribute to Eo/B recruitment. |
| doi_str_mv | 10.1016/j.clim.2014.02.013 |
| format | Article |
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Here we investigated this association in a population-based cohort. Furthermore, we analysed whether newborns Th1/Th2 balance and prenatal environmental exposure impact Eo/B recruitment. Methods In a sub-cohort of the LINA study cord blood mononuclear cells were used for methylcellulose assays to assess Eo/B differentiation. Questionnaires were recorded during pregnancy and annually thereafter. Volatile organic compounds were measured during pregnancy and cord blood cytokines after ex vivo stimulation. Results Cord blood IL-4 and IL-13 positively correlated with Eo/B. Tobacco smoke related benzene was also positively associated with Eo/B. Enhanced Eo/B numbers increased the risk for wheezing within the first 24 months. Conclusions The association between cord blood Eo/B and respiratory illnesses is not restricted to high-risk children. Prenatal environmental exposure and a Th2 milieu at birth contribute to Eo/B recruitment.</description><identifier>ISSN: 1521-6616</identifier><identifier>EISSN: 1521-7035</identifier><identifier>DOI: 10.1016/j.clim.2014.02.013</identifier><identifier>PMID: 24607604</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Allergy and Immunology ; Basophils - cytology ; Basophils - drug effects ; Basophils - immunology ; Bronchitis ; Cell Differentiation ; Cohort Studies ; Cord blood ; Environmental Exposure ; Eosinophil/basophil progenitors ; Eosinophils - cytology ; Eosinophils - drug effects ; Eosinophils - immunology ; Female ; Fetal Blood - cytology ; Fetal Stem Cells - cytology ; Fetal Stem Cells - drug effects ; Fetal Stem Cells - immunology ; Humans ; Infant ; Infant, Newborn ; LINA ; Male ; Pregnancy ; Prenatal Exposure Delayed Effects - genetics ; Prenatal Exposure Delayed Effects - immunology ; Respiratory Tract Infections - genetics ; Respiratory Tract Infections - immunology ; Surveys and Questionnaires ; Th1-Th2 Balance ; Two year old children ; Volatile Organic Compounds - adverse effects ; Wheezing</subject><ispartof>Clinical immunology (Orlando, Fla.), 2014-05, Vol.152 (1), p.68-76</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-9feb984ba4c7e056a3a97282c8e5f87432d8dade652bf8cb11522e82bbda15e23</citedby><cites>FETCH-LOGICAL-c444t-9feb984ba4c7e056a3a97282c8e5f87432d8dade652bf8cb11522e82bbda15e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1521661614000503$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24607604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Junge, Kristin M</creatorcontrib><creatorcontrib>Hörnig, Friederike</creatorcontrib><creatorcontrib>Herberth, Gunda</creatorcontrib><creatorcontrib>Röder, Stefan</creatorcontrib><creatorcontrib>Kohajda, Tibor</creatorcontrib><creatorcontrib>Rolle-Kampczyk, Ulrike</creatorcontrib><creatorcontrib>von Bergen, Martin</creatorcontrib><creatorcontrib>Borte, Michael</creatorcontrib><creatorcontrib>Simon, Jan-Christoph</creatorcontrib><creatorcontrib>Heroux, Delia</creatorcontrib><creatorcontrib>Denburg, Judah A</creatorcontrib><creatorcontrib>Lehmann, Irina</creatorcontrib><title>The LINA cohort: Cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy</title><title>Clinical immunology (Orlando, Fla.)</title><addtitle>Clin Immunol</addtitle><description>Abstract Rationale Cord blood eosinophil/basophil progenitor cells (Eo/B) of high risk infants have been shown to predict respiratory illnesses in infancy. Here we investigated this association in a population-based cohort. Furthermore, we analysed whether newborns Th1/Th2 balance and prenatal environmental exposure impact Eo/B recruitment. Methods In a sub-cohort of the LINA study cord blood mononuclear cells were used for methylcellulose assays to assess Eo/B differentiation. Questionnaires were recorded during pregnancy and annually thereafter. Volatile organic compounds were measured during pregnancy and cord blood cytokines after ex vivo stimulation. Results Cord blood IL-4 and IL-13 positively correlated with Eo/B. Tobacco smoke related benzene was also positively associated with Eo/B. Enhanced Eo/B numbers increased the risk for wheezing within the first 24 months. Conclusions The association between cord blood Eo/B and respiratory illnesses is not restricted to high-risk children. Prenatal environmental exposure and a Th2 milieu at birth contribute to Eo/B recruitment.</description><subject>Allergy and Immunology</subject><subject>Basophils - cytology</subject><subject>Basophils - drug effects</subject><subject>Basophils - immunology</subject><subject>Bronchitis</subject><subject>Cell Differentiation</subject><subject>Cohort Studies</subject><subject>Cord blood</subject><subject>Environmental Exposure</subject><subject>Eosinophil/basophil progenitors</subject><subject>Eosinophils - cytology</subject><subject>Eosinophils - drug effects</subject><subject>Eosinophils - immunology</subject><subject>Female</subject><subject>Fetal Blood - cytology</subject><subject>Fetal Stem Cells - cytology</subject><subject>Fetal Stem Cells - drug effects</subject><subject>Fetal Stem Cells - immunology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>LINA</subject><subject>Male</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects - genetics</subject><subject>Prenatal Exposure Delayed Effects - immunology</subject><subject>Respiratory Tract Infections - genetics</subject><subject>Respiratory Tract Infections - immunology</subject><subject>Surveys and Questionnaires</subject><subject>Th1-Th2 Balance</subject><subject>Two year old children</subject><subject>Volatile Organic Compounds - adverse effects</subject><subject>Wheezing</subject><issn>1521-6616</issn><issn>1521-7035</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUk1v1DAUjBCIlsIf4IB85LKpv-MghFStoFRawYFytvzxwnpJ4sVOkPLvcdgtBw5w8siaeXpvZqrqJcE1wUReH2rXh6GmmPAa0xoT9qi6JIKSTYOZeHzGUhJ5UT3L-YAxFpTKp9UF5RI3EvPLKtzvAe3uPt0gF_cxTW_QNiaPbB-jRxBzGONxH_pra_JvgI4pfoMxTDHlgsEHN6EE-RiSKX8LivPk4gAZhRGBSf1SQGdGtzyvnnSmz_Di_F5VXz-8v99-3Ow-395tb3YbxzmfNm0HtlXcGu4awEIaZtqGKuoUiE41nFGvvPEgBbWdcpaUIykoaq03RABlV9Xr09yy6Y8Z8qSHkB30vRkhzlmTRjVtOZ-J_1MFaRVTqpWFSk9Ul2LOCTp9TGEwadEE6zUNfdBrGnpNQ2OqSxpF9Oo8f7YD-D-SB_sL4e2JAMWQnwGSzi7A6IqtCdykfQz_nv_uL3mhjMGZ_jsskA9xTmOxWhOdi0B_Wfuw1oHwtQqYsV_I_LEz</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Junge, Kristin M</creator><creator>Hörnig, Friederike</creator><creator>Herberth, Gunda</creator><creator>Röder, Stefan</creator><creator>Kohajda, Tibor</creator><creator>Rolle-Kampczyk, Ulrike</creator><creator>von Bergen, Martin</creator><creator>Borte, Michael</creator><creator>Simon, Jan-Christoph</creator><creator>Heroux, Delia</creator><creator>Denburg, Judah A</creator><creator>Lehmann, Irina</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20140501</creationdate><title>The LINA cohort: Cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy</title><author>Junge, Kristin M ; Hörnig, Friederike ; Herberth, Gunda ; Röder, Stefan ; Kohajda, Tibor ; Rolle-Kampczyk, Ulrike ; von Bergen, Martin ; Borte, Michael ; Simon, Jan-Christoph ; Heroux, Delia ; Denburg, Judah A ; Lehmann, Irina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-9feb984ba4c7e056a3a97282c8e5f87432d8dade652bf8cb11522e82bbda15e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Allergy and Immunology</topic><topic>Basophils - cytology</topic><topic>Basophils - drug effects</topic><topic>Basophils - immunology</topic><topic>Bronchitis</topic><topic>Cell Differentiation</topic><topic>Cohort Studies</topic><topic>Cord blood</topic><topic>Environmental Exposure</topic><topic>Eosinophil/basophil progenitors</topic><topic>Eosinophils - cytology</topic><topic>Eosinophils - drug effects</topic><topic>Eosinophils - immunology</topic><topic>Female</topic><topic>Fetal Blood - cytology</topic><topic>Fetal Stem Cells - cytology</topic><topic>Fetal Stem Cells - drug effects</topic><topic>Fetal Stem Cells - immunology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>LINA</topic><topic>Male</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects - genetics</topic><topic>Prenatal Exposure Delayed Effects - immunology</topic><topic>Respiratory Tract Infections - genetics</topic><topic>Respiratory Tract Infections - immunology</topic><topic>Surveys and Questionnaires</topic><topic>Th1-Th2 Balance</topic><topic>Two year old children</topic><topic>Volatile Organic Compounds - adverse effects</topic><topic>Wheezing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Junge, Kristin M</creatorcontrib><creatorcontrib>Hörnig, Friederike</creatorcontrib><creatorcontrib>Herberth, Gunda</creatorcontrib><creatorcontrib>Röder, Stefan</creatorcontrib><creatorcontrib>Kohajda, Tibor</creatorcontrib><creatorcontrib>Rolle-Kampczyk, Ulrike</creatorcontrib><creatorcontrib>von Bergen, Martin</creatorcontrib><creatorcontrib>Borte, Michael</creatorcontrib><creatorcontrib>Simon, Jan-Christoph</creatorcontrib><creatorcontrib>Heroux, Delia</creatorcontrib><creatorcontrib>Denburg, Judah A</creatorcontrib><creatorcontrib>Lehmann, Irina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Clinical immunology (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Junge, Kristin M</au><au>Hörnig, Friederike</au><au>Herberth, Gunda</au><au>Röder, Stefan</au><au>Kohajda, Tibor</au><au>Rolle-Kampczyk, Ulrike</au><au>von Bergen, Martin</au><au>Borte, Michael</au><au>Simon, Jan-Christoph</au><au>Heroux, Delia</au><au>Denburg, Judah A</au><au>Lehmann, Irina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The LINA cohort: Cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy</atitle><jtitle>Clinical immunology (Orlando, Fla.)</jtitle><addtitle>Clin Immunol</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>152</volume><issue>1</issue><spage>68</spage><epage>76</epage><pages>68-76</pages><issn>1521-6616</issn><eissn>1521-7035</eissn><abstract>Abstract Rationale Cord blood eosinophil/basophil progenitor cells (Eo/B) of high risk infants have been shown to predict respiratory illnesses in infancy. Here we investigated this association in a population-based cohort. Furthermore, we analysed whether newborns Th1/Th2 balance and prenatal environmental exposure impact Eo/B recruitment. Methods In a sub-cohort of the LINA study cord blood mononuclear cells were used for methylcellulose assays to assess Eo/B differentiation. Questionnaires were recorded during pregnancy and annually thereafter. Volatile organic compounds were measured during pregnancy and cord blood cytokines after ex vivo stimulation. Results Cord blood IL-4 and IL-13 positively correlated with Eo/B. Tobacco smoke related benzene was also positively associated with Eo/B. Enhanced Eo/B numbers increased the risk for wheezing within the first 24 months. Conclusions The association between cord blood Eo/B and respiratory illnesses is not restricted to high-risk children. Prenatal environmental exposure and a Th2 milieu at birth contribute to Eo/B recruitment.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24607604</pmid><doi>10.1016/j.clim.2014.02.013</doi><tpages>9</tpages></addata></record> |
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| subjects | Allergy and Immunology Basophils - cytology Basophils - drug effects Basophils - immunology Bronchitis Cell Differentiation Cohort Studies Cord blood Environmental Exposure Eosinophil/basophil progenitors Eosinophils - cytology Eosinophils - drug effects Eosinophils - immunology Female Fetal Blood - cytology Fetal Stem Cells - cytology Fetal Stem Cells - drug effects Fetal Stem Cells - immunology Humans Infant Infant, Newborn LINA Male Pregnancy Prenatal Exposure Delayed Effects - genetics Prenatal Exposure Delayed Effects - immunology Respiratory Tract Infections - genetics Respiratory Tract Infections - immunology Surveys and Questionnaires Th1-Th2 Balance Two year old children Volatile Organic Compounds - adverse effects Wheezing |
| title | The LINA cohort: Cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy |
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