Interaction between COMT Val158Met polymorphism and childhood adversity affects reward processing in adulthood

Accumulating evidence suggests that altered dopamine transmission may increase the risk of mental disorders such as ADHD, schizophrenia or depression, possibly mediated by reward system dysfunction. This study aimed to clarify the impact of the COMT Val158Met polymorphism in interaction with environ...

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Veröffentlicht in:	NeuroImage (Orlando, Fla.) Fla.), 2016-05, Vol.132, p.556-570
Hauptverfasser:	Boecker-Schlier, Regina, Holz, Nathalie E., Buchmann, Arlette F., Blomeyer, Dorothea, Plichta, Michael M., Jennen-Steinmetz, Christine, Wolf, Isabella, Baumeister, Sarah, Treutlein, Jens, Rietschel, Marcella, Meyer-Lindenberg, Andreas, Banaschewski, Tobias, Brandeis, Daniel, Laucht, Manfred
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Childhood adversity COMT Val158Met polymorphism Dopamine Electroencephalography Functional magnetic resonance imaging Gene–environment interaction Genotype & phenotype Reward processing
Online-Zugang:	Volltext
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