Strain-specific Plasmodium falciparum multifunctional CD4+ T cell cytokine expression in Malian children immunized with the FMP2.1/AS02A vaccine candidate
Highlights • We demonstrate an AMA1-specific T cell response following vaccination. • The antigen-specific immune response was detectable in an at-risk population in Mali. • A differential pediatric immune response with clinical malaria vaccinees is shown.
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| Veröffentlicht in: | Vaccine 2016-05, Vol.34 (23), p.2546-2555 |
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| container_title | Vaccine |
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| creator | Graves, Shawna F Kouriba, Bourema Diarra, Issa Daou, Modibo Niangaly, Amadou Coulibaly, Drissa Keita, Yamoussa Laurens, Matthew B Berry, Andrea A Vekemans, Johan Ripley Ballou, W Lanar, David E Dutta, Sheetij Gray Heppner, D Soisson, Lorraine Diggs, Carter L Thera, Mahamadou A Doumbo, Ogobara K Plowe, Christopher V Sztein, Marcelo B Lyke, Kirsten E |
| description | Highlights • We demonstrate an AMA1-specific T cell response following vaccination. • The antigen-specific immune response was detectable in an at-risk population in Mali. • A differential pediatric immune response with clinical malaria vaccinees is shown. |
| doi_str_mv | 10.1016/j.vaccine.2016.04.019 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2016-05, Vol.34 (23), p.2546-2555 |
| issn | 0264-410X 1873-2518 |
| language | eng |
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| subjects | Adjuvants, Immunologic - administration & dosage Allergy and Immunology AMA1 Antibodies, Protozoan - blood Antigens, Protozoan - immunology CD4-Positive T-Lymphocytes - immunology Child Child, Preschool Cytokines - immunology FMP2.1/AS02A Humans Immunization, Secondary Infant Interferon-gamma - immunology Interleukin-17 - immunology Interleukin-2 - immunology Malaria Malaria Vaccines - therapeutic use Malaria, Falciparum - prevention & control Mali Membrane Proteins - immunology Multifunctional Pediatric Plasmodium falciparum Protozoan Proteins - immunology T cell Tumor Necrosis Factor-alpha - immunology |
| title | Strain-specific Plasmodium falciparum multifunctional CD4+ T cell cytokine expression in Malian children immunized with the FMP2.1/AS02A vaccine candidate |
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