Inhibition of let-7 augments the recruitment of epicardial cells and improves cardiac function after myocardial infarction

Abstract Heart failure due to myocardial infarction is a major cause of mortality. The microRNA (miR) family let-7 is expressed during embryonic development and is up-regulated in differentiated cells. The aim of this study was to study the role of let-7 after acute myocardial infarction (AMI). We d...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2016-05, Vol.94, p.145-152
Hauptverfasser:	Seeger, Timon, Xu, Quan-Fu, Muhly-Reinholz, Marion, Fischer, Ariane, Kremp, Eva-Maria, Zeiher, Andreas M, Dimmeler, Stefanie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Basic Helix-Loop-Helix Transcription Factors - genetics Cardiac regeneration Cardiovascular Cell Lineage Epicardial cells Epithelial-Mesenchymal Transition - genetics Epithelial-to mesenchymal transition Fibrosis Gene Expression Regulation Let-7 Male Mice Mice, Transgenic MicroRNAs - chemistry MicroRNAs - genetics Myocardial infarction Myocardial Infarction - genetics Myocardial Infarction - pathology Myocardial Infarction - physiopathology Ventricular Dysfunction - genetics
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