Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II

Activation triggers the exchange of subunits in Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), an oligomeric enzyme that is critical for learning, memory, and cardiac function. The mechanism by which subunit exchange occurs remains elusive. We show that the human CaMKII holoenzyme exists in...

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Veröffentlicht in:	eLife 2016-03, Vol.5
Hauptverfasser:	Bhattacharyya, Moitrayee, Stratton, Margaret M, Going, Catherine C, McSpadden, Ethan D, Huang, Yongjian, Susa, Anna C, Elleman, Anna, Cao, Yumeng Melody, Pappireddi, Nishant, Burkhardt, Pawel, Gee, Christine L, Barros, Tiago, Schulman, Howard, Williams, Evan R, Kuriyan, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Humans Models, Biological Models, Molecular Molecular Conformation Protein Multimerization Protein Subunits - metabolism
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