Differential proteome analysis of conditioned media to detect Smad4 regulated secreted biomarkers in colon cancer

Smad4 is a tumor suppressor gene primarily involved in carcinogenesis of the pancreas and colon. The functional inactivation of Smad4 is a late step genetically. In pancreatic carcinogenesis, loss of Smad4 marks the transition to invasive growth. In colorectal cancers, the frequency of Smad4 inactiv...

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Veröffentlicht in:	Proteomics (Weinheim) 2005-07, Vol.5 (10), p.2587-2601
Hauptverfasser:	Volmer, Martin W., Stühler, Kai, Zapatka, Marc, Schöneck, Anna, Klein-Scory, Susanne, Schmiegel, Wolff, Meyer, Helmut E., Schwarte-Waldhoff, Irmgard
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Biomarkers, Tumor - chemistry Biomarkers, Tumor - isolation & purification Cell Division Cell Line, Tumor Colonic Neoplasms - metabolism Colorectal cancer Culture Media, Conditioned - chemistry Differential secretome analysis DNA-Binding Proteins - metabolism Electrophoresis, Gel, Two-Dimensional - methods Enzymes - isolation & purification Enzymes - metabolism Fluorescence difference gel electrophoresis Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Genes, Tumor Suppressor Humans Invasion suppressor Medical sciences Miscellaneous Models, Biological Peptide Fragments - chemistry Peptide Fragments - isolation & purification Protease Inhibitors Proteins Proteome Smad4 Protein Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Trans-Activators - metabolism Trypsin Tumor suppressor Smad4 Tumors
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