Glial reaction to volkensin-induced selective degeneration of central neurons

Volkensin, a highly toxic protein retrogradely transported through axons, was used to target primary neuronal death in brainstem precerebellar relays after injection in the cerebellar cortex of rats. The reaction of astrocytes and microglia was studied with immunohistochemistry in the inferior oliva...

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Veröffentlicht in:	Brain research bulletin 2001-03, Vol.54 (4), p.353-361
Hauptverfasser:	Cevolani, Daniela, Bentivoglio, Marina, Strocchi, Paola
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD Antigens, Neoplasm Antigens, Surface Astrocytes Astrocytes - drug effects Astrocytes - metabolism Avian Proteins Basigin Biological and medical sciences Blood Proteins Cell Death - physiology Development. Senescence. Regeneration. Transplantation Fundamental and applied biological sciences. Psychology Glial Fibrillary Acidic Protein - metabolism Glycoproteins H-2 Antigens - metabolism Histocompatibility Antigens Class II - metabolism Major histocompatibility complex Male Membrane Glycoproteins - metabolism Microglia Microglia - drug effects Microglia - metabolism N-Glycosyl Hydrolases Neurodegeneration Neurotoxins - administration & dosage Neurotoxins - toxicity Olivary Nucleus - drug effects Olivary Nucleus - metabolism Plant Lectins Plant Proteins - administration & dosage Plant Proteins - toxicity Pons - drug effects Pons - metabolism Rats Rats, Sprague-Dawley Ribosome Inactivating Proteins, Type 2 Ricin - administration & dosage Ricin - toxicity Toxins Vertebrates: nervous system and sense organs volkensin
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