Progressive vascular remodelling, endothelial dysfunction and stiffness in mesenteric resistance arteries in a rodent model of chronic kidney disease

Abstract Chronic kidney disease (CKD) and hypertension are co-morbid conditions both associated with altered resistance artery structure, biomechanics and function. We examined these characteristics in mesenteric artery together with renal function and systolic blood pressure (SBP) changes in the Le...

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Veröffentlicht in:	Vascular pharmacology 2016-06, Vol.81, p.42-52
Hauptverfasser:	Quek, K.J, Boyd, R, Ameer, O.Z, Zangerl, B, Butlin, M, Murphy, T.V, Avolio, A.P, Phillips, J.K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure Cardiovascular Disease Models, Animal Dose-Response Relationship, Drug Elastic Modulus Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - pathology Endothelium, Vascular - physiopathology Female Hypertension Male Mesenteric Arteries - drug effects Mesenteric Arteries - pathology Mesenteric Arteries - physiopathology Mesenteric resistance artery Polycystic kidney disease Rats, Inbred Lew Renal Insufficiency, Chronic - genetics Renal Insufficiency, Chronic - pathology Renal Insufficiency, Chronic - physiopathology Time Factors Vascular Remodeling Vascular remodelling Vascular Resistance - drug effects Vascular Stiffness Vasoconstriction - drug effects Vasoconstrictor Agents - pharmacology Vasodilation - drug effects Vasodilator Agents - pharmacology
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