Use of rat models to mimic alterations in iron homeostasis during human alcohol abuse and cirrhosis

With alcoholism, there are marked disturbances in iron homeostasis that are linked to alterations in serum transferrin and ferritin concentrations. This study identifies rat models of alcohol abuse that closely mimic these disturbances. Male rats were placed in one of the following three protocols:...

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Veröffentlicht in:	Alcohol (Fayetteville, N.Y.) N.Y.), 2001-02, Vol.23 (2), p.71-81
Hauptverfasser:	Gentry-Nielsen, Martha J, Preheim, Laurel C, Lyman, Katrina N, McDonough, Kathleen H, Potter, Barry J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Alcoholism - blood Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Central Nervous System Depressants - adverse effects Disease Models, Animal Ethanol - adverse effects Ferritins - blood Homeostasis - drug effects Homeostasis - physiology Iron Iron - blood Liver Cirrhosis, Alcoholic - blood Liver disease Male Medical sciences Rats Rats, Sprague-Dawley Serum ferritin Small animal models Toxicology Transferrin Transferrin - metabolism
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