Comparison of estimated daily per capita intakes of flavouring substances with no-observed-effect levels from animal studies
A study was conducted to determine the margins of safety between no-observed-effect levels (NOELs) and daily per capita intake of flavouring substances evaluated by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) using the safety evaluation procedure for flavouring substances. The safet...
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| Veröffentlicht in: | Food and chemical toxicology 2001-04, Vol.39 (4), p.331-354 |
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| creator | Munro, I.C Kennepohl, E |
| description | A study was conducted to determine the margins of safety between no-observed-effect levels (NOELs) and daily per capita intake of flavouring substances evaluated by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) using the safety evaluation procedure for flavouring substances. The safety evaluation procedure provides a practical method for integrating data on intake, structure–activity relationships, metabolism and toxicity to evaluate flavouring substances. The comparison of NOELs to intake reinforces the fact that the margins of safety between intake of flavouring substances and their representative NOELs is very large. 98% of flavouring substances have margins of safety greater than 1000, illustrating that even if intake was underestimated by several fold, in almost every case, a wide margin of safety would still exist. |
| doi_str_mv | 10.1016/S0278-6915(00)00145-9 |
| format | Article |
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Kennepohl, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-9600c5ab8bc094176924c4f744474bfbd23c69144a19c4f1965033c836cc49db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Eating</topic><topic>Exposure</topic><topic>Flavoring Agents - administration & dosage</topic><topic>Flavoring Agents - toxicity</topic><topic>Flavouring substance</topic><topic>Food Additives - administration & dosage</topic><topic>Food Additives - toxicity</topic><topic>Food toxicology</topic><topic>Global Health</topic><topic>Humans</topic><topic>Margin of safety</topic><topic>Medical sciences</topic><topic>Models, Animal</topic><topic>No-Observed-Adverse-Effect Level</topic><topic>no-observed-effect levels</topic><topic>Risk Assessment</topic><topic>Safety</topic><topic>Safety assessment</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Munro, I.C</creatorcontrib><creatorcontrib>Kennepohl, E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Munro, I.C</au><au>Kennepohl, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of estimated daily per capita intakes of flavouring substances with no-observed-effect levels from animal studies</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>39</volume><issue>4</issue><spage>331</spage><epage>354</epage><pages>331-354</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>A study was conducted to determine the margins of safety between no-observed-effect levels (NOELs) and daily per capita intake of flavouring substances evaluated by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) using the safety evaluation procedure for flavouring substances. 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| ispartof | Food and chemical toxicology, 2001-04, Vol.39 (4), p.331-354 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Biological and medical sciences Eating Exposure Flavoring Agents - administration & dosage Flavoring Agents - toxicity Flavouring substance Food Additives - administration & dosage Food Additives - toxicity Food toxicology Global Health Humans Margin of safety Medical sciences Models, Animal No-Observed-Adverse-Effect Level no-observed-effect levels Risk Assessment Safety Safety assessment Toxicology |
| title | Comparison of estimated daily per capita intakes of flavouring substances with no-observed-effect levels from animal studies |
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