Successful treatment of acute aluminium phosphide poisoning: possible benefit of coconut oil
Aluminium phosphide is used to control rodents and pests in grain storage facilities. It produces phosphine gas, which is a mitochondrial poison. Unfortunately, there is no known antidote for aluminium phosphide intoxication, but our recent experience with a case showed that rapid prevention of abso...
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| Veröffentlicht in: | Human & experimental toxicology 2005-04, Vol.24 (4), p.215-218 |
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| creator | Shadnia, Shahin Rahimi, Mojgan Pajoumand, Abdolkarim Rasouli, Mohammad-Hosein Abdollahi, Mohammad |
| description | Aluminium phosphide is used to control rodents and pests in grain storage facilities. It produces phosphine gas, which is a mitochondrial poison. Unfortunately, there is no known antidote for aluminium phosphide intoxication, but our recent experience with a case showed that rapid prevention of absorption by coconut oil might be helpful. In the present case, we used the same protocol in a 28-year-old man who had ingested a lethal amount (12 g) of aluminium phosphide with suicidal intent and was admitted to hospital approximately 6 hours postingestion. The patient had signs and symptoms of severe toxicity, and his clinical course included metabolic acidosis and liver dysfunction. Treatment consisted of gastric lavage with potassium permanganate solution, oral administration of charcoal and sorbitol suspension, intravenous administration of sodium bicarbonate, magnesium sulphate and calcium gluconate, and oral administration of sodium bicarbonate and coconut oil. Conservative and supportive therapy in the Intensive Care Unit was also provided. The patient survived following rapid treatment and supportive care. It is concluded that coconut oil has a positive clinical significance and can be added to the treatment protocol of acute aluminium phosphide poisoning in humans. |
| doi_str_mv | 10.1191/0960327105ht513oa |
| format | Article |
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It produces phosphine gas, which is a mitochondrial poison. Unfortunately, there is no known antidote for aluminium phosphide intoxication, but our recent experience with a case showed that rapid prevention of absorption by coconut oil might be helpful. In the present case, we used the same protocol in a 28-year-old man who had ingested a lethal amount (12 g) of aluminium phosphide with suicidal intent and was admitted to hospital approximately 6 hours postingestion. The patient had signs and symptoms of severe toxicity, and his clinical course included metabolic acidosis and liver dysfunction. Treatment consisted of gastric lavage with potassium permanganate solution, oral administration of charcoal and sorbitol suspension, intravenous administration of sodium bicarbonate, magnesium sulphate and calcium gluconate, and oral administration of sodium bicarbonate and coconut oil. Conservative and supportive therapy in the Intensive Care Unit was also provided. The patient survived following rapid treatment and supportive care. It is concluded that coconut oil has a positive clinical significance and can be added to the treatment protocol of acute aluminium phosphide poisoning in humans.</description><identifier>ISSN: 0960-3271</identifier><identifier>EISSN: 1477-0903</identifier><identifier>DOI: 10.1191/0960327105ht513oa</identifier><identifier>PMID: 15957538</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Acute Disease ; Adult ; Aluminum Compounds - poisoning ; Biological and medical sciences ; Chemical and industrial products toxicology. 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It produces phosphine gas, which is a mitochondrial poison. Unfortunately, there is no known antidote for aluminium phosphide intoxication, but our recent experience with a case showed that rapid prevention of absorption by coconut oil might be helpful. In the present case, we used the same protocol in a 28-year-old man who had ingested a lethal amount (12 g) of aluminium phosphide with suicidal intent and was admitted to hospital approximately 6 hours postingestion. The patient had signs and symptoms of severe toxicity, and his clinical course included metabolic acidosis and liver dysfunction. Treatment consisted of gastric lavage with potassium permanganate solution, oral administration of charcoal and sorbitol suspension, intravenous administration of sodium bicarbonate, magnesium sulphate and calcium gluconate, and oral administration of sodium bicarbonate and coconut oil. Conservative and supportive therapy in the Intensive Care Unit was also provided. The patient survived following rapid treatment and supportive care. It is concluded that coconut oil has a positive clinical significance and can be added to the treatment protocol of acute aluminium phosphide poisoning in humans.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Aluminum Compounds - poisoning</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. 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Toxic occupational diseases</topic><topic>Coconut Oil</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>Phosphines - poisoning</topic><topic>Plant Oils - therapeutic use</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shadnia, Shahin</creatorcontrib><creatorcontrib>Rahimi, Mojgan</creatorcontrib><creatorcontrib>Pajoumand, Abdolkarim</creatorcontrib><creatorcontrib>Rasouli, Mohammad-Hosein</creatorcontrib><creatorcontrib>Abdollahi, Mohammad</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Environment Abstracts</collection><jtitle>Human & experimental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Shadnia, Shahin</au><au>Rahimi, Mojgan</au><au>Pajoumand, Abdolkarim</au><au>Rasouli, Mohammad-Hosein</au><au>Abdollahi, Mohammad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful treatment of acute aluminium phosphide poisoning: possible benefit of coconut oil</atitle><jtitle>Human & experimental toxicology</jtitle><addtitle>Hum Exp Toxicol</addtitle><date>2005-04-01</date><risdate>2005</risdate><volume>24</volume><issue>4</issue><spage>215</spage><epage>218</epage><pages>215-218</pages><issn>0960-3271</issn><eissn>1477-0903</eissn><abstract>Aluminium phosphide is used to control rodents and pests in grain storage facilities. It produces phosphine gas, which is a mitochondrial poison. Unfortunately, there is no known antidote for aluminium phosphide intoxication, but our recent experience with a case showed that rapid prevention of absorption by coconut oil might be helpful. In the present case, we used the same protocol in a 28-year-old man who had ingested a lethal amount (12 g) of aluminium phosphide with suicidal intent and was admitted to hospital approximately 6 hours postingestion. The patient had signs and symptoms of severe toxicity, and his clinical course included metabolic acidosis and liver dysfunction. Treatment consisted of gastric lavage with potassium permanganate solution, oral administration of charcoal and sorbitol suspension, intravenous administration of sodium bicarbonate, magnesium sulphate and calcium gluconate, and oral administration of sodium bicarbonate and coconut oil. Conservative and supportive therapy in the Intensive Care Unit was also provided. The patient survived following rapid treatment and supportive care. It is concluded that coconut oil has a positive clinical significance and can be added to the treatment protocol of acute aluminium phosphide poisoning in humans.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>15957538</pmid><doi>10.1191/0960327105ht513oa</doi><tpages>4</tpages></addata></record> |
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| ispartof | Human & experimental toxicology, 2005-04, Vol.24 (4), p.215-218 |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Acute Disease Adult Aluminum Compounds - poisoning Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Coconut Oil Humans Male Medical sciences Metals and various inorganic compounds Pesticides, fertilizers and other agrochemicals toxicology Phosphines - poisoning Plant Oils - therapeutic use Toxicology |
| title | Successful treatment of acute aluminium phosphide poisoning: possible benefit of coconut oil |
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