Palladium-Catalyzed Ortho-Arylation of Carbamate-Protected Estrogens

Palladium-Catalyzed Ortho-Arylation of Carbamate-Protected Estrogens

The palladium-catalyzed ortho-arylation of diethyl carbamate-protected estrone and estriol with aryl iodides gives the 2-arylated analogues. Subsequent removal of the carbamate directing group furnishes 2-arylated estrone, estradiol, or estriol depending on the method used.

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Veröffentlicht in:Journal of organic chemistry 2016-05, Vol.81 (9), p.3473-3478
Hauptverfasser: Bedford, Robin B, Brenner, Peter B, Durrant, Steven J, Gallagher, Timothy, Méndez-Gálvez, Carolina, Montgomery, Michelle
Format: Artikel
Sprache:eng
Schlagworte:
Carbamates - chemistry
Catalysis
Estriol - chemistry
Estrogens - chemistry
Molecular Structure
Palladium - chemistry
Stereoisomerism
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Zusammenfassung:The palladium-catalyzed ortho-arylation of diethyl carbamate-protected estrone and estriol with aryl iodides gives the 2-arylated analogues. Subsequent removal of the carbamate directing group furnishes 2-arylated estrone, estradiol, or estriol depending on the method used.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.6b00532