Reversal of right ventricular remodeling by dichloroacetate is related to inhibition of mitochondria-dependent apoptosis

Most patients with pulmonary arterial hypertension die from right ventricular failure (RVF). Right ventricular (RV) myocardial apoptosis has an important role in RVF and is regulated by the mitochondria. Dichloroacetate (DCA) can improve cardiac function in RVF, but whether it can regulate myocardia...

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Veröffentlicht in:	Hypertension research 2016-05, Vol.39 (5), p.302-311
Hauptverfasser:	Sun, Xiao-Qing, Zhang, Rui, Zhang, Hong-Da, Yuan, Ping, Wang, Xiao-Jian, Zhao, Qin-Hua, Wang, Lan, Jiang, Rong, Jan Bogaard, Harm, Jing, Zhi-Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Arterial Pressure - drug effects Dichloroacetic Acid - pharmacology Disease Models, Animal Heart Ventricles - drug effects Heart Ventricles - metabolism Hemodynamics - drug effects Male Mitochondria - drug effects Mitochondria - metabolism Monocrotaline - pharmacology Rats Rats, Sprague-Dawley Ventricular Remodeling - drug effects Ventricular Remodeling - physiology
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