Conjunctival Autograft Versus Amniotic Membrane Transplantation After Double Pterygium Excision: A Randomized Trial
PURPOSE:To compare the outcome of amniotic membrane transplantation (AMT) and conjunctival autograft (CAG) after pterygium excision in patients with nasal and temporal pterygium (double pterygium) in the same eye. METHODS:Tertiary care medical center. A total of 33 eyes of 33 patients with previousl...
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| Veröffentlicht in: | Cornea 2016-06, Vol.35 (6), p.823-826 |
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| creator | Prajna, N Venkatesh Devi, Lumbini Seeniraj, Suganya K Keenan, Jeremy D |
| description | PURPOSE:To compare the outcome of amniotic membrane transplantation (AMT) and conjunctival autograft (CAG) after pterygium excision in patients with nasal and temporal pterygium (double pterygium) in the same eye.
METHODS:Tertiary care medical center. A total of 33 eyes of 33 patients with previously unoperated double pterygium were enrolled in the randomized trial, of which 31 remained in follow-up at 1 year. Eyes with double pterygium were randomized to either nasal AMT and temporal CAG (nasal AMT group) or to temporal AMT and nasal CAG (temporal AMT group). The primary prespecified outcome was pterygium recurrence at the excised site 1 year after pterygium excision.
RESULTS:At 1 year none of the 31 pterygia randomized to CAG showed recurrence in either the nasal or temporal location (0%, 95% confidence interval, 0%–11.2%). In contrast, 8 of 31 pterygia randomized to AMT exhibited recurrence at 1 year (25.8%, 95% confidence interval, 11.9%–44.6%), with 4 temporal recurrences and 4 nasal recurrences. The recurrence rate was significantly higher for AMT than CAG (P = 0.005primary analysis), but not significantly different between the nasal and temporal sites (P ≥ 0.99).
CONCLUSIONS:The use of CAG in pterygium surgery led to fewer recurrences than AMT, irrespective of the site of replacement. |
| doi_str_mv | 10.1097/ICO.0000000000000812 |
| format | Article |
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METHODS:Tertiary care medical center. A total of 33 eyes of 33 patients with previously unoperated double pterygium were enrolled in the randomized trial, of which 31 remained in follow-up at 1 year. Eyes with double pterygium were randomized to either nasal AMT and temporal CAG (nasal AMT group) or to temporal AMT and nasal CAG (temporal AMT group). The primary prespecified outcome was pterygium recurrence at the excised site 1 year after pterygium excision.
RESULTS:At 1 year none of the 31 pterygia randomized to CAG showed recurrence in either the nasal or temporal location (0%, 95% confidence interval, 0%–11.2%). In contrast, 8 of 31 pterygia randomized to AMT exhibited recurrence at 1 year (25.8%, 95% confidence interval, 11.9%–44.6%), with 4 temporal recurrences and 4 nasal recurrences. The recurrence rate was significantly higher for AMT than CAG (P = 0.005primary analysis), but not significantly different between the nasal and temporal sites (P ≥ 0.99).
CONCLUSIONS:The use of CAG in pterygium surgery led to fewer recurrences than AMT, irrespective of the site of replacement.</description><identifier>ISSN: 0277-3740</identifier><identifier>EISSN: 1536-4798</identifier><identifier>DOI: 10.1097/ICO.0000000000000812</identifier><identifier>PMID: 27055214</identifier><language>eng</language><publisher>United States: Copyright Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Adult ; Amnion - transplantation ; Autografts ; Conjunctiva - transplantation ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Pterygium - diagnosis ; Pterygium - surgery ; Recurrence</subject><ispartof>Cornea, 2016-06, Vol.35 (6), p.823-826</ispartof><rights>Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3052-be81a50f937360e94b3e5482fefed58dd281e56b4e145fdb74ef7479d448991c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27055214$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prajna, N Venkatesh</creatorcontrib><creatorcontrib>Devi, Lumbini</creatorcontrib><creatorcontrib>Seeniraj, Suganya K</creatorcontrib><creatorcontrib>Keenan, Jeremy D</creatorcontrib><title>Conjunctival Autograft Versus Amniotic Membrane Transplantation After Double Pterygium Excision: A Randomized Trial</title><title>Cornea</title><addtitle>Cornea</addtitle><description>PURPOSE:To compare the outcome of amniotic membrane transplantation (AMT) and conjunctival autograft (CAG) after pterygium excision in patients with nasal and temporal pterygium (double pterygium) in the same eye.
METHODS:Tertiary care medical center. A total of 33 eyes of 33 patients with previously unoperated double pterygium were enrolled in the randomized trial, of which 31 remained in follow-up at 1 year. Eyes with double pterygium were randomized to either nasal AMT and temporal CAG (nasal AMT group) or to temporal AMT and nasal CAG (temporal AMT group). The primary prespecified outcome was pterygium recurrence at the excised site 1 year after pterygium excision.
RESULTS:At 1 year none of the 31 pterygia randomized to CAG showed recurrence in either the nasal or temporal location (0%, 95% confidence interval, 0%–11.2%). In contrast, 8 of 31 pterygia randomized to AMT exhibited recurrence at 1 year (25.8%, 95% confidence interval, 11.9%–44.6%), with 4 temporal recurrences and 4 nasal recurrences. The recurrence rate was significantly higher for AMT than CAG (P = 0.005primary analysis), but not significantly different between the nasal and temporal sites (P ≥ 0.99).
CONCLUSIONS:The use of CAG in pterygium surgery led to fewer recurrences than AMT, irrespective of the site of replacement.</description><subject>Adult</subject><subject>Amnion - transplantation</subject><subject>Autografts</subject><subject>Conjunctiva - transplantation</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pterygium - diagnosis</subject><subject>Pterygium - surgery</subject><subject>Recurrence</subject><issn>0277-3740</issn><issn>1536-4798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PFTEUhhujkSv6Dwjp0s1A22mnHXaTCygJBmPQ7aQzcwqFzvTSDxB_vSUXDXHhWfQ06fOetg9Ce5QcUNLKw7P1xQF5WYqyV2hFRd1UXLbqNVoRJmVVS0520LsYbwojZcPeoh0miRCM8hWKa7_c5GVM9l473OXkr4I2Cf-AEHPE3bxYn-yIv8A8BL0Avixr3Di9JJ2sX3BnEgR87PPgAH8t-8crm2d88nO0sZwf4Q5_08vkZ_sLppK22r1Hb4x2ET489130_fTkcv25Or_4dLbuzquxJoJVAyiqBTFtLeuGQMuHGgRXzICBSahpYoqCaAYOlAszDZKDkeXnE-eqbelY76KP27mb4O8yxNTPNo7gyuPB59hTqQqvGiYKyrfoGHyMAUy_CXbW4bGnpH_S3Rfd_b-6S2z_-YY8zDD9Df3xWwC1BR68K27ircsPEPpr0C5d_3_2b00FjTE</recordid><startdate>201606</startdate><enddate>201606</enddate><creator>Prajna, N Venkatesh</creator><creator>Devi, Lumbini</creator><creator>Seeniraj, Suganya K</creator><creator>Keenan, Jeremy D</creator><general>Copyright Wolters Kluwer Health, Inc. All rights reserved</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201606</creationdate><title>Conjunctival Autograft Versus Amniotic Membrane Transplantation After Double Pterygium Excision: A Randomized Trial</title><author>Prajna, N Venkatesh ; Devi, Lumbini ; Seeniraj, Suganya K ; Keenan, Jeremy D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3052-be81a50f937360e94b3e5482fefed58dd281e56b4e145fdb74ef7479d448991c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Amnion - transplantation</topic><topic>Autografts</topic><topic>Conjunctiva - transplantation</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pterygium - diagnosis</topic><topic>Pterygium - surgery</topic><topic>Recurrence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prajna, N Venkatesh</creatorcontrib><creatorcontrib>Devi, Lumbini</creatorcontrib><creatorcontrib>Seeniraj, Suganya K</creatorcontrib><creatorcontrib>Keenan, Jeremy D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cornea</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prajna, N Venkatesh</au><au>Devi, Lumbini</au><au>Seeniraj, Suganya K</au><au>Keenan, Jeremy D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conjunctival Autograft Versus Amniotic Membrane Transplantation After Double Pterygium Excision: A Randomized Trial</atitle><jtitle>Cornea</jtitle><addtitle>Cornea</addtitle><date>2016-06</date><risdate>2016</risdate><volume>35</volume><issue>6</issue><spage>823</spage><epage>826</epage><pages>823-826</pages><issn>0277-3740</issn><eissn>1536-4798</eissn><abstract>PURPOSE:To compare the outcome of amniotic membrane transplantation (AMT) and conjunctival autograft (CAG) after pterygium excision in patients with nasal and temporal pterygium (double pterygium) in the same eye.
METHODS:Tertiary care medical center. A total of 33 eyes of 33 patients with previously unoperated double pterygium were enrolled in the randomized trial, of which 31 remained in follow-up at 1 year. Eyes with double pterygium were randomized to either nasal AMT and temporal CAG (nasal AMT group) or to temporal AMT and nasal CAG (temporal AMT group). The primary prespecified outcome was pterygium recurrence at the excised site 1 year after pterygium excision.
RESULTS:At 1 year none of the 31 pterygia randomized to CAG showed recurrence in either the nasal or temporal location (0%, 95% confidence interval, 0%–11.2%). In contrast, 8 of 31 pterygia randomized to AMT exhibited recurrence at 1 year (25.8%, 95% confidence interval, 11.9%–44.6%), with 4 temporal recurrences and 4 nasal recurrences. The recurrence rate was significantly higher for AMT than CAG (P = 0.005primary analysis), but not significantly different between the nasal and temporal sites (P ≥ 0.99).
CONCLUSIONS:The use of CAG in pterygium surgery led to fewer recurrences than AMT, irrespective of the site of replacement.</abstract><cop>United States</cop><pub>Copyright Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>27055214</pmid><doi>10.1097/ICO.0000000000000812</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0277-3740 |
| ispartof | Cornea, 2016-06, Vol.35 (6), p.823-826 |
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| language | eng |
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| source | Journals@Ovid Ovid Autoload; MEDLINE |
| subjects | Adult Amnion - transplantation Autografts Conjunctiva - transplantation Female Follow-Up Studies Humans Male Middle Aged Pterygium - diagnosis Pterygium - surgery Recurrence |
| title | Conjunctival Autograft Versus Amniotic Membrane Transplantation After Double Pterygium Excision: A Randomized Trial |
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