Hydromorphone Compared With Diacetylmorphine for Long-term Opioid Dependence: A Randomized Clinical Trial

IMPORTANCE: Diacetylmorphine hydrochloride (the active ingredient in heroin), delivered under supervision, is effective for the treatment of severe opioid use disorder. However, owing to political and regulatory barriers, it is not available in many settings around the world, which limits the option...

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Veröffentlicht in:	JAMA psychiatry (Chicago, Ill.) Ill.), 2016-05, Vol.73 (5), p.447-455
Hauptverfasser:	Oviedo-Joekes, Eugenia, Guh, Daphne, Brissette, Suzanne, Marchand, Kirsten, MacDonald, Scott, Lock, Kurt, Harrison, Scott, Janmohamed, Amin, Anis, Aslam H, Krausz, Michael, Marsh, David C, Schechter, Martin T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult British Columbia Convulsions & seizures Double-Blind Method Drug Administration Schedule Drug dosages Drug use Female Follow-Up Studies Heroin Heroin - adverse effects Heroin - therapeutic use Heroin Dependence - rehabilitation Humans Hydromorphone - adverse effects Hydromorphone - therapeutic use Injections, Intravenous Intention to Treat Analysis Intervention Long-Term Care Male Middle Aged Needle-Exchange Programs Street Drugs Substance Abuse Detection Substance abuse treatment
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