A high number of IgG4-positive cells in gastric cancer tissue is associated with tumor progression and poor prognosis
IgG4-related disease is a newly defined disease characterized by elevated serum IgG4 levels and infiltration of affected organs by IgG4-positive plasma cells. Recently, increased IgG4 levels were reported to be closely related with malignancy. To assess the relationship between IgG4 and the progress...
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| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2016-05, Vol.468 (5), p.549-557 |
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| creator | Miyatani, Kozo Saito, Hiroaki Murakami, Yuki Watanabe, Joji Kuroda, Hirohiko Matsunaga, Tomoyuki Fukumoto, Yoji Osaki, Tomohiro Nakayama, Yuji Umekita, Yoshihisa Ikeguchi, Masahide |
| description | IgG4-related disease is a newly defined disease characterized by elevated serum IgG4 levels and infiltration of affected organs by IgG4-positive plasma cells. Recently, increased IgG4 levels were reported to be closely related with malignancy. To assess the relationship between IgG4 and the progression of gastric cancer, we immunohistochemically stained in this study gastric cancer tissue samples for IgG4-positive cells using an anti-IgG4 antibody. In addition, pre- and postoperative serum concentrations of IgG4 were measured, using an enzyme-linked immunosorbent assay. In gastric cancer samples, the number of CD138-positive plasma cells was significantly lower and the number of IgG4-positive cells significantly higher than in non-cancerous gastric mucosa. The number of IgG4-positive cells was significantly correlated with gross tumor appearance, tumor depth, lymph node metastasis, venous invasion, and lymphatic invasion. Prognosis was significantly poorer in patients with a high number of IgG4-positive cells than in those with a low number. Multivariate analysis indicated that both the number of IgG4-positive cells and the depth of tumor invasion were independently prognostic of survival. In conclusion, in gastric cancer, the number of IgG4-positive cells is increased and this is closely associated with gastric cancer progression. |
| doi_str_mv | 10.1007/s00428-016-1914-0 |
| format | Article |
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Recently, increased IgG4 levels were reported to be closely related with malignancy. To assess the relationship between IgG4 and the progression of gastric cancer, we immunohistochemically stained in this study gastric cancer tissue samples for IgG4-positive cells using an anti-IgG4 antibody. In addition, pre- and postoperative serum concentrations of IgG4 were measured, using an enzyme-linked immunosorbent assay. In gastric cancer samples, the number of CD138-positive plasma cells was significantly lower and the number of IgG4-positive cells significantly higher than in non-cancerous gastric mucosa. The number of IgG4-positive cells was significantly correlated with gross tumor appearance, tumor depth, lymph node metastasis, venous invasion, and lymphatic invasion. Prognosis was significantly poorer in patients with a high number of IgG4-positive cells than in those with a low number. Multivariate analysis indicated that both the number of IgG4-positive cells and the depth of tumor invasion were independently prognostic of survival. In conclusion, in gastric cancer, the number of IgG4-positive cells is increased and this is closely associated with gastric cancer progression.</description><identifier>ISSN: 0945-6317</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s00428-016-1914-0</identifier><identifier>PMID: 26951261</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adenocarcinoma - pathology ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - analysis ; Disease Progression ; Female ; Gastric Mucosa - pathology ; Humans ; Immunoenzyme Techniques - methods ; Immunoglobulin G - immunology ; Lymphatic Metastasis - pathology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate analysis ; Neoplasm Invasiveness ; Original Article ; Pathology ; Prognosis ; Stomach Neoplasms - diagnosis ; Stomach Neoplasms - immunology ; Stomach Neoplasms - pathology ; Tumors</subject><ispartof>Virchows Archiv : an international journal of pathology, 2016-05, Vol.468 (5), p.549-557</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-3a800ac8cf85aa079435de359f13d511fb7d3be096fdb958850228a8fddd3ad33</citedby><cites>FETCH-LOGICAL-c415t-3a800ac8cf85aa079435de359f13d511fb7d3be096fdb958850228a8fddd3ad33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00428-016-1914-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00428-016-1914-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26951261$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyatani, Kozo</creatorcontrib><creatorcontrib>Saito, Hiroaki</creatorcontrib><creatorcontrib>Murakami, Yuki</creatorcontrib><creatorcontrib>Watanabe, Joji</creatorcontrib><creatorcontrib>Kuroda, Hirohiko</creatorcontrib><creatorcontrib>Matsunaga, Tomoyuki</creatorcontrib><creatorcontrib>Fukumoto, Yoji</creatorcontrib><creatorcontrib>Osaki, Tomohiro</creatorcontrib><creatorcontrib>Nakayama, Yuji</creatorcontrib><creatorcontrib>Umekita, Yoshihisa</creatorcontrib><creatorcontrib>Ikeguchi, Masahide</creatorcontrib><title>A high number of IgG4-positive cells in gastric cancer tissue is associated with tumor progression and poor prognosis</title><title>Virchows Archiv : an international journal of pathology</title><addtitle>Virchows Arch</addtitle><addtitle>Virchows Arch</addtitle><description>IgG4-related disease is a newly defined disease characterized by elevated serum IgG4 levels and infiltration of affected organs by IgG4-positive plasma cells. Recently, increased IgG4 levels were reported to be closely related with malignancy. To assess the relationship between IgG4 and the progression of gastric cancer, we immunohistochemically stained in this study gastric cancer tissue samples for IgG4-positive cells using an anti-IgG4 antibody. In addition, pre- and postoperative serum concentrations of IgG4 were measured, using an enzyme-linked immunosorbent assay. In gastric cancer samples, the number of CD138-positive plasma cells was significantly lower and the number of IgG4-positive cells significantly higher than in non-cancerous gastric mucosa. The number of IgG4-positive cells was significantly correlated with gross tumor appearance, tumor depth, lymph node metastasis, venous invasion, and lymphatic invasion. Prognosis was significantly poorer in patients with a high number of IgG4-positive cells than in those with a low number. Multivariate analysis indicated that both the number of IgG4-positive cells and the depth of tumor invasion were independently prognostic of survival. In conclusion, in gastric cancer, the number of IgG4-positive cells is increased and this is closely associated with gastric cancer progression.</description><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Gastric Mucosa - pathology</subject><subject>Humans</subject><subject>Immunoenzyme Techniques - methods</subject><subject>Immunoglobulin G - immunology</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Neoplasm Invasiveness</subject><subject>Original Article</subject><subject>Pathology</subject><subject>Prognosis</subject><subject>Stomach Neoplasms - diagnosis</subject><subject>Stomach Neoplasms - immunology</subject><subject>Stomach Neoplasms - 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Academic</collection><jtitle>Virchows Archiv : an international journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyatani, Kozo</au><au>Saito, Hiroaki</au><au>Murakami, Yuki</au><au>Watanabe, Joji</au><au>Kuroda, Hirohiko</au><au>Matsunaga, Tomoyuki</au><au>Fukumoto, Yoji</au><au>Osaki, Tomohiro</au><au>Nakayama, Yuji</au><au>Umekita, Yoshihisa</au><au>Ikeguchi, Masahide</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A high number of IgG4-positive cells in gastric cancer tissue is associated with tumor progression and poor prognosis</atitle><jtitle>Virchows Archiv : an international journal of pathology</jtitle><stitle>Virchows Arch</stitle><addtitle>Virchows Arch</addtitle><date>2016-05-01</date><risdate>2016</risdate><volume>468</volume><issue>5</issue><spage>549</spage><epage>557</epage><pages>549-557</pages><issn>0945-6317</issn><eissn>1432-2307</eissn><abstract>IgG4-related disease is a newly defined disease characterized by elevated serum IgG4 levels and infiltration of affected organs by IgG4-positive plasma cells. Recently, increased IgG4 levels were reported to be closely related with malignancy. To assess the relationship between IgG4 and the progression of gastric cancer, we immunohistochemically stained in this study gastric cancer tissue samples for IgG4-positive cells using an anti-IgG4 antibody. In addition, pre- and postoperative serum concentrations of IgG4 were measured, using an enzyme-linked immunosorbent assay. In gastric cancer samples, the number of CD138-positive plasma cells was significantly lower and the number of IgG4-positive cells significantly higher than in non-cancerous gastric mucosa. The number of IgG4-positive cells was significantly correlated with gross tumor appearance, tumor depth, lymph node metastasis, venous invasion, and lymphatic invasion. Prognosis was significantly poorer in patients with a high number of IgG4-positive cells than in those with a low number. Multivariate analysis indicated that both the number of IgG4-positive cells and the depth of tumor invasion were independently prognostic of survival. In conclusion, in gastric cancer, the number of IgG4-positive cells is increased and this is closely associated with gastric cancer progression.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26951261</pmid><doi>10.1007/s00428-016-1914-0</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma - pathology Adult Aged Aged, 80 and over Biomarkers, Tumor - analysis Disease Progression Female Gastric Mucosa - pathology Humans Immunoenzyme Techniques - methods Immunoglobulin G - immunology Lymphatic Metastasis - pathology Male Medicine Medicine & Public Health Middle Aged Multivariate analysis Neoplasm Invasiveness Original Article Pathology Prognosis Stomach Neoplasms - diagnosis Stomach Neoplasms - immunology Stomach Neoplasms - pathology Tumors |
| title | A high number of IgG4-positive cells in gastric cancer tissue is associated with tumor progression and poor prognosis |
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