Challenging Argatroban Management of a Child on Extracorporeal Support and Subsequent Heart Transplant

A 6-year-old child developed heparin-induced thrombocytopenia while on extracorporeal life support. Hours after a difficult transition from heparin to argatroban for anticoagulation therapy, the child underwent heart transplantation. Intraoperative management was plagued with circuit thrombus format...

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Veröffentlicht in:	Seminars in cardiothoracic and vascular anesthesia 2016-06, Vol.20 (2), p.168-174
Hauptverfasser:	Latham, Gregory J., Jefferis Kirk, Christa, Falconer, Amy, Dickey, Renee, Albers, Erin L., McMullan, David Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Antithrombins - therapeutic use Cardiopulmonary Bypass - adverse effects Child Exchange Transfusion, Whole Blood Extracorporeal Membrane Oxygenation Heart Transplantation Heparin - adverse effects Hirudins Humans Male Peptide Fragments - therapeutic use Pipecolic Acids - pharmacology Pipecolic Acids - therapeutic use Recombinant Proteins - therapeutic use Thrombocytopenia - diagnosis Thrombocytopenia - drug therapy
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