Mitochondrial Inhibitory Factor Protein 1 Functions as an Endogenous Inhibitor for Coupling Factor 6

ABSTRACT Coupling factor 6 (CF6) forces a counter‐clockwise rotation of plasma membrane F1Fo complex unlike a proton‐mediated clockwise rotation in the mitochondria, resulting in ATP hydrolysis, proton import, and apoptosis. Inhibitory peptide 1 (IF1) inhibits a unidirectional counter‐clockwise rota...

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Veröffentlicht in:	Journal of cellular biochemistry 2016-07, Vol.117 (7), p.1680-1687
Hauptverfasser:	Kawai, Misato, Osanai, Tomohiro, Tanaka, Makoto, Magota, Koji, Tomita, Hirofumi, Okumura, Ken
Format:	Artikel
Sprache:	eng
Schlagworte:	APOPTOSIS ATP ATPase Inhibitory Protein COUPLING FACTOR 6 ECTO-F1FO COMPLEX Exosomes - genetics Exosomes - metabolism HEK293 Cells Humans INHIBITORY PEPTIDE 1 INTRACELLULAR ACIDOSIS Mitochondrial Proton-Translocating ATPases - antagonists & inhibitors Mitochondrial Proton-Translocating ATPases - genetics Mitochondrial Proton-Translocating ATPases - metabolism Oxidative Phosphorylation Coupling Factors - antagonists & inhibitors Oxidative Phosphorylation Coupling Factors - genetics Oxidative Phosphorylation Coupling Factors - metabolism Phosphorylation - genetics Protein Transport - genetics Proteins - genetics Proteins - metabolism Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Proton-Translocating ATPases - genetics Proton-Translocating ATPases - metabolism Transfection
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