Resveratrol shows neuronal and vascular-protective effects in older, obese, streptozotocin-induced diabetic rats
Diabetes-induced CVD is the most significant complication of prolonged hyperglycaemia. The aim of this study was to determine whether resveratrol, a polyphenol antioxidant compound, when administered at a dose that can be reasonably obtained through supplementation could prevent the development of c...
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| Veröffentlicht in: | British journal of nutrition 2016-06, Vol.115 (11), p.1911-1918 |
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| creator | Phyu, Hnin Ei Irwin, Jordon Candice Vella, Rebecca Kate Fenning, Andrew Stuart |
| description | Diabetes-induced CVD is the most significant complication of prolonged hyperglycaemia. The aim of this study was to determine whether resveratrol, a polyphenol antioxidant compound, when administered at a dose that can be reasonably obtained through supplementation could prevent the development of cardiovascular complications in older, obese, diabetic rats. Diabetes was induced in 6-month old, obese, male Wistar rats via a single intravenous dose of streptozotocin (65 mg/kg). Randomly selected animals were administered resveratrol (2 mg/kg) via oral gavage daily for 8 weeks. Body weights, blood glucose levels, food intake and water consumption were monitored, and assessments of vascular reactivity, tactile allodynia and left ventricular function were performed. Resveratrol therapy significantly improved tactile allodynia and vascular contractile functionality in diabetic rats (P |
| doi_str_mv | 10.1017/S0007114516001069 |
| format | Article |
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The aim of this study was to determine whether resveratrol, a polyphenol antioxidant compound, when administered at a dose that can be reasonably obtained through supplementation could prevent the development of cardiovascular complications in older, obese, diabetic rats. Diabetes was induced in 6-month old, obese, male Wistar rats via a single intravenous dose of streptozotocin (65 mg/kg). Randomly selected animals were administered resveratrol (2 mg/kg) via oral gavage daily for 8 weeks. Body weights, blood glucose levels, food intake and water consumption were monitored, and assessments of vascular reactivity, tactile allodynia and left ventricular function were performed. Resveratrol therapy significantly improved tactile allodynia and vascular contractile functionality in diabetic rats (P<0·05). There were no significant changes in standardised vasorelaxation responses, plasma glucose concentrations, water consumption, body weight, left ventricular hypertrophy, kidney hypertrophy, heart rate or left ventricular compliance with resveratrol administration. Resveratrol-mediated improvements in vascular and nerve function in old, obese, diabetic rats were associated with its reported antioxidant effects. Resveratrol did not improve cardiac function nor mitigate the classic clinical symptoms of diabetes mellitus (i.e. hyperglycaemia, polydypsia and a failure to thrive). This suggests that supplementation with resveratrol at a dose achievable with commercially available supplements would not produce significant cardioprotective effects in people with diabetes mellitus.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114516001069</identifier><identifier>PMID: 27153202</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Analgesics - pharmacology ; Analgesics - therapeutic use ; Animals ; Antioxidants ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Body weight ; Cardiovascular disease ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - prevention & control ; Diabetes ; Diabetes Mellitus, Experimental - complications ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - pathology ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - physiology ; Heart rate ; Hyperalgesia - drug therapy ; Male ; Metabolism and Metabolic Studies ; Muscle Contraction - drug effects ; Nervous System - drug effects ; Nutrition research ; Obesity - complications ; Obesity - drug therapy ; Obesity - pathology ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Polyphenols ; Polyphenols - pharmacology ; Polyphenols - therapeutic use ; Random Allocation ; Rats, Wistar ; Stilbenes - pharmacology ; Stilbenes - therapeutic use ; Water consumption</subject><ispartof>British journal of nutrition, 2016-06, Vol.115 (11), p.1911-1918</ispartof><rights>Copyright © The Authors 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-745a1585836fca71024f1c6d10f95838e0f0b10e9f5e7964162a8dd4fb98a9a13</citedby><cites>FETCH-LOGICAL-c439t-745a1585836fca71024f1c6d10f95838e0f0b10e9f5e7964162a8dd4fb98a9a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114516001069/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,27923,27924,55627</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27153202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Phyu, Hnin Ei</creatorcontrib><creatorcontrib>Irwin, Jordon Candice</creatorcontrib><creatorcontrib>Vella, Rebecca Kate</creatorcontrib><creatorcontrib>Fenning, Andrew Stuart</creatorcontrib><title>Resveratrol shows neuronal and vascular-protective effects in older, obese, streptozotocin-induced diabetic rats</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Diabetes-induced CVD is the most significant complication of prolonged hyperglycaemia. The aim of this study was to determine whether resveratrol, a polyphenol antioxidant compound, when administered at a dose that can be reasonably obtained through supplementation could prevent the development of cardiovascular complications in older, obese, diabetic rats. Diabetes was induced in 6-month old, obese, male Wistar rats via a single intravenous dose of streptozotocin (65 mg/kg). Randomly selected animals were administered resveratrol (2 mg/kg) via oral gavage daily for 8 weeks. Body weights, blood glucose levels, food intake and water consumption were monitored, and assessments of vascular reactivity, tactile allodynia and left ventricular function were performed. Resveratrol therapy significantly improved tactile allodynia and vascular contractile functionality in diabetic rats (P<0·05). There were no significant changes in standardised vasorelaxation responses, plasma glucose concentrations, water consumption, body weight, left ventricular hypertrophy, kidney hypertrophy, heart rate or left ventricular compliance with resveratrol administration. Resveratrol-mediated improvements in vascular and nerve function in old, obese, diabetic rats were associated with its reported antioxidant effects. Resveratrol did not improve cardiac function nor mitigate the classic clinical symptoms of diabetes mellitus (i.e. hyperglycaemia, polydypsia and a failure to thrive). This suggests that supplementation with resveratrol at a dose achievable with commercially available supplements would not produce significant cardioprotective effects in people with diabetes mellitus.</description><subject>Analgesics - pharmacology</subject><subject>Analgesics - therapeutic use</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Body weight</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Experimental - complications</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - pathology</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - physiology</subject><subject>Heart rate</subject><subject>Hyperalgesia - 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Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Phyu, Hnin Ei</au><au>Irwin, Jordon Candice</au><au>Vella, Rebecca Kate</au><au>Fenning, Andrew Stuart</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resveratrol shows neuronal and vascular-protective effects in older, obese, streptozotocin-induced diabetic rats</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2016-06-14</date><risdate>2016</risdate><volume>115</volume><issue>11</issue><spage>1911</spage><epage>1918</epage><pages>1911-1918</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><abstract>Diabetes-induced CVD is the most significant complication of prolonged hyperglycaemia. The aim of this study was to determine whether resveratrol, a polyphenol antioxidant compound, when administered at a dose that can be reasonably obtained through supplementation could prevent the development of cardiovascular complications in older, obese, diabetic rats. Diabetes was induced in 6-month old, obese, male Wistar rats via a single intravenous dose of streptozotocin (65 mg/kg). Randomly selected animals were administered resveratrol (2 mg/kg) via oral gavage daily for 8 weeks. Body weights, blood glucose levels, food intake and water consumption were monitored, and assessments of vascular reactivity, tactile allodynia and left ventricular function were performed. Resveratrol therapy significantly improved tactile allodynia and vascular contractile functionality in diabetic rats (P<0·05). There were no significant changes in standardised vasorelaxation responses, plasma glucose concentrations, water consumption, body weight, left ventricular hypertrophy, kidney hypertrophy, heart rate or left ventricular compliance with resveratrol administration. Resveratrol-mediated improvements in vascular and nerve function in old, obese, diabetic rats were associated with its reported antioxidant effects. Resveratrol did not improve cardiac function nor mitigate the classic clinical symptoms of diabetes mellitus (i.e. hyperglycaemia, polydypsia and a failure to thrive). This suggests that supplementation with resveratrol at a dose achievable with commercially available supplements would not produce significant cardioprotective effects in people with diabetes mellitus.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>27153202</pmid><doi>10.1017/S0007114516001069</doi><tpages>8</tpages></addata></record> |
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| subjects | Analgesics - pharmacology Analgesics - therapeutic use Animals Antioxidants Antioxidants - pharmacology Antioxidants - therapeutic use Body weight Cardiovascular disease Cardiovascular Diseases - etiology Cardiovascular Diseases - prevention & control Diabetes Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - pathology Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Heart rate Hyperalgesia - drug therapy Male Metabolism and Metabolic Studies Muscle Contraction - drug effects Nervous System - drug effects Nutrition research Obesity - complications Obesity - drug therapy Obesity - pathology Plant Extracts - pharmacology Plant Extracts - therapeutic use Polyphenols Polyphenols - pharmacology Polyphenols - therapeutic use Random Allocation Rats, Wistar Stilbenes - pharmacology Stilbenes - therapeutic use Water consumption |
| title | Resveratrol shows neuronal and vascular-protective effects in older, obese, streptozotocin-induced diabetic rats |
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