The activity of seminal creatine kinase is increased in the presence of pentoxifylline
Summary Creatine kinase enzyme (CK) is indispensable for sperm function because it catalyses the regeneration of ATP from the chemical shuttle between creatine and creatine phosphate. Here, we measured CK activity of human spermatozoa in the presence of pentoxifylline (PF), a xanthine derivative dru...
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| Veröffentlicht in: | Andrologia 2016-06, Vol.48 (5), p.603-604 |
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| creator | Banihani, S. A. Abu-Alhayjaa, R. F. |
| description | Summary
Creatine kinase enzyme (CK) is indispensable for sperm function because it catalyses the regeneration of ATP from the chemical shuttle between creatine and creatine phosphate. Here, we measured CK activity of human spermatozoa in the presence of pentoxifylline (PF), a xanthine derivative drug primarily used to treat peripheral vascular function. Nine semen samples from different males were subjected to swim up, incubated with PF and tested for CK activity using the kinetic spectrophotometric method. The CK activity of spermatozoa significantly increased after addition of PF at 5 mm compared with the control (with 0.0 mm PF). Given that PF has been identified as a sperm motility enhancer and that CK is crucial for adequate sperm motion; then, the aptitude of PF to enhance sperm motility may be modulated by increasing CK activity. |
| doi_str_mv | 10.1111/and.12486 |
| format | Article |
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Creatine kinase enzyme (CK) is indispensable for sperm function because it catalyses the regeneration of ATP from the chemical shuttle between creatine and creatine phosphate. Here, we measured CK activity of human spermatozoa in the presence of pentoxifylline (PF), a xanthine derivative drug primarily used to treat peripheral vascular function. Nine semen samples from different males were subjected to swim up, incubated with PF and tested for CK activity using the kinetic spectrophotometric method. The CK activity of spermatozoa significantly increased after addition of PF at 5 mm compared with the control (with 0.0 mm PF). Given that PF has been identified as a sperm motility enhancer and that CK is crucial for adequate sperm motion; then, the aptitude of PF to enhance sperm motility may be modulated by increasing CK activity.</description><identifier>ISSN: 0303-4569</identifier><identifier>EISSN: 1439-0272</identifier><identifier>DOI: 10.1111/and.12486</identifier><identifier>PMID: 26395279</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>creatine kinase ; Creatine Kinase - metabolism ; Humans ; In Vitro Techniques ; Kinetics ; Male ; pentoxifylline ; Pentoxifylline - pharmacology ; semen ; Semen - drug effects ; Semen - enzymology ; Sperm Motility - drug effects ; Spermatozoa - drug effects ; Spermatozoa - enzymology</subject><ispartof>Andrologia, 2016-06, Vol.48 (5), p.603-604</ispartof><rights>2015 Blackwell Verlag GmbH</rights><rights>2015 Blackwell Verlag GmbH.</rights><rights>Copyright © 2016 Blackwell Verlag GmbH</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4266-83fe6c6b9a45746d2b0ed3083c2c4fdd40c3fb486320692119e8c38e66e2296f3</citedby><cites>FETCH-LOGICAL-c4266-83fe6c6b9a45746d2b0ed3083c2c4fdd40c3fb486320692119e8c38e66e2296f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fand.12486$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fand.12486$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26395279$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Banihani, S. A.</creatorcontrib><creatorcontrib>Abu-Alhayjaa, R. F.</creatorcontrib><title>The activity of seminal creatine kinase is increased in the presence of pentoxifylline</title><title>Andrologia</title><addtitle>Andrologia</addtitle><description>Summary
Creatine kinase enzyme (CK) is indispensable for sperm function because it catalyses the regeneration of ATP from the chemical shuttle between creatine and creatine phosphate. Here, we measured CK activity of human spermatozoa in the presence of pentoxifylline (PF), a xanthine derivative drug primarily used to treat peripheral vascular function. Nine semen samples from different males were subjected to swim up, incubated with PF and tested for CK activity using the kinetic spectrophotometric method. The CK activity of spermatozoa significantly increased after addition of PF at 5 mm compared with the control (with 0.0 mm PF). Given that PF has been identified as a sperm motility enhancer and that CK is crucial for adequate sperm motion; then, the aptitude of PF to enhance sperm motility may be modulated by increasing CK activity.</description><subject>creatine kinase</subject><subject>Creatine Kinase - metabolism</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Kinetics</subject><subject>Male</subject><subject>pentoxifylline</subject><subject>Pentoxifylline - pharmacology</subject><subject>semen</subject><subject>Semen - drug effects</subject><subject>Semen - enzymology</subject><subject>Sperm Motility - drug effects</subject><subject>Spermatozoa - drug effects</subject><subject>Spermatozoa - enzymology</subject><issn>0303-4569</issn><issn>1439-0272</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLAzEUhYMoWqoL_4AMuNHFaF5NJstStQpaF9YHbkKauYPR6UxNptr-e9OOuhC8XEhu-M4h9yC0T_AJiXVqqvyEUJ6JDdQhnKkUU0k3UQczzFLeE2oH7YXwimPxnpScb6MdKpjqUak66GH8AomxjftwzTKpiyTA1FWmTKwH07gKkrc4BkhcSFy1egyQx1vSRN3MQ4DKwko3g6qpF65YlmVU7aKtwpQB9r7PLrq_OB8PLtPr2-HVoH-dWk6FSDNWgLBiokz8Ghc5nWDIGc6YpZYXec6xZcUk7sYoFooSoiCzLAMhgFIlCtZFR63vzNfvcwiNnrpgoSxNBfU8aCIzySVnsbvo8A_6Ws99XLWlMBN0TR23lPV1CB4KPfNuavxSE6xXeeuYt17nHdmDb8f5ZAr5L_mTbgROW-DTlbD830n3R2c_lmmrcKGBxa_C-DctJJM9_Tga6punkbojz1xj9gU8EJdF</recordid><startdate>201606</startdate><enddate>201606</enddate><creator>Banihani, S. A.</creator><creator>Abu-Alhayjaa, R. F.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201606</creationdate><title>The activity of seminal creatine kinase is increased in the presence of pentoxifylline</title><author>Banihani, S. A. ; Abu-Alhayjaa, R. F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4266-83fe6c6b9a45746d2b0ed3083c2c4fdd40c3fb486320692119e8c38e66e2296f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>creatine kinase</topic><topic>Creatine Kinase - metabolism</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Kinetics</topic><topic>Male</topic><topic>pentoxifylline</topic><topic>Pentoxifylline - pharmacology</topic><topic>semen</topic><topic>Semen - drug effects</topic><topic>Semen - enzymology</topic><topic>Sperm Motility - drug effects</topic><topic>Spermatozoa - drug effects</topic><topic>Spermatozoa - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Banihani, S. A.</creatorcontrib><creatorcontrib>Abu-Alhayjaa, R. F.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Andrologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Banihani, S. A.</au><au>Abu-Alhayjaa, R. F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The activity of seminal creatine kinase is increased in the presence of pentoxifylline</atitle><jtitle>Andrologia</jtitle><addtitle>Andrologia</addtitle><date>2016-06</date><risdate>2016</risdate><volume>48</volume><issue>5</issue><spage>603</spage><epage>604</epage><pages>603-604</pages><issn>0303-4569</issn><eissn>1439-0272</eissn><abstract>Summary
Creatine kinase enzyme (CK) is indispensable for sperm function because it catalyses the regeneration of ATP from the chemical shuttle between creatine and creatine phosphate. Here, we measured CK activity of human spermatozoa in the presence of pentoxifylline (PF), a xanthine derivative drug primarily used to treat peripheral vascular function. Nine semen samples from different males were subjected to swim up, incubated with PF and tested for CK activity using the kinetic spectrophotometric method. The CK activity of spermatozoa significantly increased after addition of PF at 5 mm compared with the control (with 0.0 mm PF). Given that PF has been identified as a sperm motility enhancer and that CK is crucial for adequate sperm motion; then, the aptitude of PF to enhance sperm motility may be modulated by increasing CK activity.</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>26395279</pmid><doi>10.1111/and.12486</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Andrologia, 2016-06, Vol.48 (5), p.603-604 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | creatine kinase Creatine Kinase - metabolism Humans In Vitro Techniques Kinetics Male pentoxifylline Pentoxifylline - pharmacology semen Semen - drug effects Semen - enzymology Sperm Motility - drug effects Spermatozoa - drug effects Spermatozoa - enzymology |
| title | The activity of seminal creatine kinase is increased in the presence of pentoxifylline |
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