Cell‐Surface MMP‐9 Protein Is a Novel Functional Marker to Identify and Separate Proangiogenic Cells from Early Endothelial Progenitor Cells Derived from CD133+ Cells

To develop cell therapies for ischemic diseases, endothelial progenitor cells (EPCs) have been expected to play a pivotal role in vascular regeneration. It is desirable to use a molecular marker that is related to the function of the cells. Here, a quantitative polymerase chain reaction array reveal...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2016-05, Vol.34 (5), p.1251-1262
Hauptverfasser:	Kanayasu‐Toyoda, Toshie, Tanaka, Takeshi, Kikuchi, Yutaka, Uchida, Eriko, Matsuyama, Akifumi, Yamaguchi, Teruhide
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen - metabolism Angiogenesis Animals Biomarkers - metabolism CD133 Cell Fractionation Cell Membrane - enzymology Cell Separation Cell therapy Endothelial progenitor cells Endothelial Progenitor Cells - cytology Endothelial Progenitor Cells - drug effects Endothelial Progenitor Cells - metabolism Flow Cytometry Gene Expression Profiling Genes Hindlimb - blood supply Hindlimb - pathology Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Hyaluronoglucosaminidase - pharmacology Interleukin-8 - metabolism Ischemia - pathology Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinase Inhibitors - pharmacology Matrix metalloproteinases Mice Neovascularization, Physiologic - drug effects RNA, Messenger - genetics RNA, Messenger - metabolism Stem cells
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