Continuous low-dose feeding of highly active pharmaceutical ingredients in hot-melt extrusion

Context: Manufacturing solid low-dose pharmaceutical products has always the homogeneity challenge. In continuous manufacturing, there is the additional challenge of feeding active pharmaceutical ingredient (API) dry powder at low rates. This paper presents a method for feeding API particles into a...

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Veröffentlicht in:	Drug development and industrial pharmacy 2016-08, Vol.42 (8), p.1360-1364
Hauptverfasser:	Llusa, Marcos, Mohr, Stefan, Baumgartner, Ramona, Paudel, Amrit, Koscher, Gerold, Khinast, Johannes
Format:	Artikel
Sprache:	eng
Schlagworte:	API homogeneity Chemistry, Pharmaceutical - methods continuous manufacturing Hot Temperature hot-melt extrusion Ibuprofen - chemistry liquid feeding low-dose solid products Pharmaceutical Preparations - chemistry Powders - chemistry Solvents - chemistry Suspensions - chemistry Technology, Pharmaceutical - methods
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