Modulation of Hexadecyl-LPA-Mediated Activation of Mast Cells and Microglia by a Chemical Probe for LPA5

Mast cells and microglia play a critical role in innate immunity and inflammation and can be activated by a wide range of endogenous and exogenous stimuli. Lysophosphatidic acid (LPA) has recently been reported to activate mast cells and microglia. Using the human mast cell line HMC‐1 and the mouse...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2016-05, Vol.17 (9), p.861-865
Hauptverfasser:	Kozian, Detlef H., von Haeften, Elisabeth, Joho, Sabrina, Czechtizky, Werngard, Anumala, Upendra R., Roux, Pascale, Dudda, Angela, Evers, Andreas, Nazare, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Cell Line Cell Membrane Permeability - drug effects Chemokine CCL2 - metabolism Gene Expression - drug effects Half-Life Humans inflammation inhibitors Kinetics lysophosphatidic acids Lysophospholipids - chemistry Lysophospholipids - pharmacokinetics Lysophospholipids - pharmacology Male mast cells Mast Cells - cytology Mast Cells - drug effects Mast Cells - metabolism Mice Mice, Inbred C57BL microglia Microglia - cytology Microglia - drug effects Microglia - metabolism Microsomes, Liver - metabolism Receptors, Lysophosphatidic Acid - antagonists & inhibitors Receptors, Lysophosphatidic Acid - genetics Receptors, Lysophosphatidic Acid - metabolism Rodents
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