Predicting the Occurrence of Sticking during Tablet Production by Shear Testing of a Pharmaceutical Powder

Sticking is a failure of pharmaceutical production that occurs when a powder containing a large amount of adhesive is being tableted. This is most frequently observed when long-term tableting is carried out, making it extremely difficult to predict its occurrence during the tablet formula design sta...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2016/05/01, Vol.64(5), pp.512-516
Hauptverfasser:	Nakamura, Shohei, Otsuka, Natsuki, Yoshino, Yukari, Sakamoto, Takatoshi, Yuasa, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	ibuprofen Ibuprofen - chemistry internal friction angle Particle Size Powders - chemical synthesis Powders - chemistry shear stress sticking sticking index Stress, Mechanical Surface Properties Tablets - chemical synthesis Tablets - chemistry wall friction angle
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