Effect of mild whole body hyperthermia on cytotoxic action of N-methyl- N′-nitro- N-nitrosoguanidine in Swiss mice
Studies were carried out to ascertain the efficacy of mild whole body hyperthermia (WBH) as a modifier of N-methyl- N′-nitro- N-nitrosoguanidine (MNNG) cytotoxicity in mice. Adult Swiss male mice, 6–8 weeks old, weighing about 25 g were exposed to mild WBH (39°C, 1 h) in a precision temperature cont...
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| Veröffentlicht in: | Toxicology letters 2001-04, Vol.121 (1), p.63-68 |
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| container_title | Toxicology letters |
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| creator | Bagewadikar, Raghavendra S. Patil, Manohar S. Zaidi, Asifa K. Subramanian, Mylvaganan Kaklij, Gangadhar S. |
| description | Studies were carried out to ascertain the efficacy of mild whole body hyperthermia (WBH) as a modifier of
N-methyl-
N′-nitro-
N-nitrosoguanidine (MNNG) cytotoxicity in mice. Adult Swiss male mice, 6–8 weeks old, weighing about 25 g were exposed to mild WBH (39°C, 1 h) in a precision temperature controlled environmental chamber maintained at 50–60% relative humidity. Twenty-four hours after treatment, animals were administered with different doses of MNNG either by intraperitoneal (i.p.) injections or by feeding through drinking water and were monitored for survival. The studies revealed that the exposure of animals to mild WBH, 24 h prior to MNNG administration results in an increase in survival and recovery in mean body weight compared with those administered with MNNG only. This suggests that prior WBH treatment can effectively reduce the MNNG cytotoxicity in mice. |
| doi_str_mv | 10.1016/S0378-4274(01)00316-2 |
| format | Article |
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N-methyl-
N′-nitro-
N-nitrosoguanidine (MNNG) cytotoxicity in mice. Adult Swiss male mice, 6–8 weeks old, weighing about 25 g were exposed to mild WBH (39°C, 1 h) in a precision temperature controlled environmental chamber maintained at 50–60% relative humidity. Twenty-four hours after treatment, animals were administered with different doses of MNNG either by intraperitoneal (i.p.) injections or by feeding through drinking water and were monitored for survival. The studies revealed that the exposure of animals to mild WBH, 24 h prior to MNNG administration results in an increase in survival and recovery in mean body weight compared with those administered with MNNG only. This suggests that prior WBH treatment can effectively reduce the MNNG cytotoxicity in mice.</description><identifier>ISSN: 0378-4274</identifier><identifier>EISSN: 1879-3169</identifier><identifier>DOI: 10.1016/S0378-4274(01)00316-2</identifier><identifier>PMID: 11312038</identifier><identifier>CODEN: TOLED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Biological and medical sciences ; Body Weight - drug effects ; Carcinogenesis, carcinogens and anticarcinogens ; Carcinogens - toxicity ; Cell Survival - drug effects ; Chemical agents ; Cytotoxicity ; Drinking - drug effects ; Hypothermia, Induced ; Intestinal Neoplasms - chemically induced ; Intestinal Neoplasms - pathology ; Lung Neoplasms - chemically induced ; Lung Neoplasms - pathology ; Medical sciences ; Methylnitronitrosoguanidine - toxicity ; Mice ; MNNG ; N-Methyl-N'-nitro-N-nitrosoguanidine ; Splenomegaly - chemically induced ; Splenomegaly - pathology ; Time Factors ; Tumors ; Whole body hyperthermia</subject><ispartof>Toxicology letters, 2001-04, Vol.121 (1), p.63-68</ispartof><rights>2001 Elsevier Science Ireland Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c368t-19abb35c78eefb3204cc22801423ddf6fd412d2013b29ceefc35678eeeb3762e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0378-4274(01)00316-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=965077$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11312038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bagewadikar, Raghavendra S.</creatorcontrib><creatorcontrib>Patil, Manohar S.</creatorcontrib><creatorcontrib>Zaidi, Asifa K.</creatorcontrib><creatorcontrib>Subramanian, Mylvaganan</creatorcontrib><creatorcontrib>Kaklij, Gangadhar S.</creatorcontrib><title>Effect of mild whole body hyperthermia on cytotoxic action of N-methyl- N′-nitro- N-nitrosoguanidine in Swiss mice</title><title>Toxicology letters</title><addtitle>Toxicol Lett</addtitle><description>Studies were carried out to ascertain the efficacy of mild whole body hyperthermia (WBH) as a modifier of
N-methyl-
N′-nitro-
N-nitrosoguanidine (MNNG) cytotoxicity in mice. Adult Swiss male mice, 6–8 weeks old, weighing about 25 g were exposed to mild WBH (39°C, 1 h) in a precision temperature controlled environmental chamber maintained at 50–60% relative humidity. Twenty-four hours after treatment, animals were administered with different doses of MNNG either by intraperitoneal (i.p.) injections or by feeding through drinking water and were monitored for survival. The studies revealed that the exposure of animals to mild WBH, 24 h prior to MNNG administration results in an increase in survival and recovery in mean body weight compared with those administered with MNNG only. This suggests that prior WBH treatment can effectively reduce the MNNG cytotoxicity in mice.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Carcinogens - toxicity</subject><subject>Cell Survival - drug effects</subject><subject>Chemical agents</subject><subject>Cytotoxicity</subject><subject>Drinking - drug effects</subject><subject>Hypothermia, Induced</subject><subject>Intestinal Neoplasms - chemically induced</subject><subject>Intestinal Neoplasms - pathology</subject><subject>Lung Neoplasms - chemically induced</subject><subject>Lung Neoplasms - pathology</subject><subject>Medical sciences</subject><subject>Methylnitronitrosoguanidine - toxicity</subject><subject>Mice</subject><subject>MNNG</subject><subject>N-Methyl-N'-nitro-N-nitrosoguanidine</subject><subject>Splenomegaly - chemically induced</subject><subject>Splenomegaly - pathology</subject><subject>Time Factors</subject><subject>Tumors</subject><subject>Whole body hyperthermia</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQhy0EokvhEUCWkBAcDP6T2MmpQlWhlapyKJwtxx6zRkm82F5KbjwTj8ST1NtdlWNPHo--n2f0GaGXjL5nlMkP11SojjRcNW8pe0epYJLwR2jFOtWTeukfo9U9coSe5fyDUiob2T5FR4wJxqnoVqiceQ-24OjxFEaHb9ZxBDxEt-D1soFU1pCmYHCcsV1KLPF3sNjYEmqjZq7IBGW9jARf_fvzl8yhpFjrfZHj962Zgwsz4DDj65uQc51i4Tl64s2Y4cXhPEbfPp19PT0nl18-X5x-vCRWyK4Q1pthEK1VHYAfBKeNtZx3lDVcOOeldw3jjlMmBt7byljRyh0Mg1CSgzhGb_bvblL8uYVc9BSyhXE0M8Rt1kx1qqFKVrDdg7ZunRN4vUlhMmnRjOqdbn2nW-9casr0nW7Na-7VYcB2mMD9Tx38VuD1ATDZmtEnM9uQ77letlSpSp3sKagyfgVIOtsAswUXUv0c7WJ4YJFb_U6dzg</recordid><startdate>20010408</startdate><enddate>20010408</enddate><creator>Bagewadikar, Raghavendra S.</creator><creator>Patil, Manohar S.</creator><creator>Zaidi, Asifa K.</creator><creator>Subramanian, Mylvaganan</creator><creator>Kaklij, Gangadhar S.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20010408</creationdate><title>Effect of mild whole body hyperthermia on cytotoxic action of N-methyl- N′-nitro- N-nitrosoguanidine in Swiss mice</title><author>Bagewadikar, Raghavendra S. ; Patil, Manohar S. ; Zaidi, Asifa K. ; Subramanian, Mylvaganan ; Kaklij, Gangadhar S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-19abb35c78eefb3204cc22801423ddf6fd412d2013b29ceefc35678eeeb3762e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Carcinogens - toxicity</topic><topic>Cell Survival - drug effects</topic><topic>Chemical agents</topic><topic>Cytotoxicity</topic><topic>Drinking - drug effects</topic><topic>Hypothermia, Induced</topic><topic>Intestinal Neoplasms - chemically induced</topic><topic>Intestinal Neoplasms - pathology</topic><topic>Lung Neoplasms - chemically induced</topic><topic>Lung Neoplasms - pathology</topic><topic>Medical sciences</topic><topic>Methylnitronitrosoguanidine - toxicity</topic><topic>Mice</topic><topic>MNNG</topic><topic>N-Methyl-N'-nitro-N-nitrosoguanidine</topic><topic>Splenomegaly - chemically induced</topic><topic>Splenomegaly - pathology</topic><topic>Time Factors</topic><topic>Tumors</topic><topic>Whole body hyperthermia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bagewadikar, Raghavendra S.</creatorcontrib><creatorcontrib>Patil, Manohar S.</creatorcontrib><creatorcontrib>Zaidi, Asifa K.</creatorcontrib><creatorcontrib>Subramanian, Mylvaganan</creatorcontrib><creatorcontrib>Kaklij, Gangadhar S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bagewadikar, Raghavendra S.</au><au>Patil, Manohar S.</au><au>Zaidi, Asifa K.</au><au>Subramanian, Mylvaganan</au><au>Kaklij, Gangadhar S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of mild whole body hyperthermia on cytotoxic action of N-methyl- N′-nitro- N-nitrosoguanidine in Swiss mice</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>2001-04-08</date><risdate>2001</risdate><volume>121</volume><issue>1</issue><spage>63</spage><epage>68</epage><pages>63-68</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><coden>TOLED5</coden><abstract>Studies were carried out to ascertain the efficacy of mild whole body hyperthermia (WBH) as a modifier of
N-methyl-
N′-nitro-
N-nitrosoguanidine (MNNG) cytotoxicity in mice. Adult Swiss male mice, 6–8 weeks old, weighing about 25 g were exposed to mild WBH (39°C, 1 h) in a precision temperature controlled environmental chamber maintained at 50–60% relative humidity. Twenty-four hours after treatment, animals were administered with different doses of MNNG either by intraperitoneal (i.p.) injections or by feeding through drinking water and were monitored for survival. The studies revealed that the exposure of animals to mild WBH, 24 h prior to MNNG administration results in an increase in survival and recovery in mean body weight compared with those administered with MNNG only. This suggests that prior WBH treatment can effectively reduce the MNNG cytotoxicity in mice.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>11312038</pmid><doi>10.1016/S0378-4274(01)00316-2</doi><tpages>6</tpages></addata></record> |
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| ispartof | Toxicology letters, 2001-04, Vol.121 (1), p.63-68 |
| issn | 0378-4274 1879-3169 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Body Weight - drug effects Carcinogenesis, carcinogens and anticarcinogens Carcinogens - toxicity Cell Survival - drug effects Chemical agents Cytotoxicity Drinking - drug effects Hypothermia, Induced Intestinal Neoplasms - chemically induced Intestinal Neoplasms - pathology Lung Neoplasms - chemically induced Lung Neoplasms - pathology Medical sciences Methylnitronitrosoguanidine - toxicity Mice MNNG N-Methyl-N'-nitro-N-nitrosoguanidine Splenomegaly - chemically induced Splenomegaly - pathology Time Factors Tumors Whole body hyperthermia |
| title | Effect of mild whole body hyperthermia on cytotoxic action of N-methyl- N′-nitro- N-nitrosoguanidine in Swiss mice |
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