Improving the therapeutic index of CpG oligodeoxynucleotides by intralymphatic administration

Signal transduction initiated by TLR such as TLR9, a natural receptor for unmethylated cytosine‐guanine‐rich motifs (CpG), results in activation of transcription factors, including NF‐κB, with substantial impact on the innate and adaptive immunity. However, practical application of new adjuvants suc...

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