Sulphostin, a Novel Inhibitor of Dipeptidyl Peptidases IV (DPPIV) That Stimulates Hematopoiesis in Mice

CD26, a membrane-bound ectopeptidase, is known as an activated T cell marker with dipeptidyl peptidase IV (DPPIV) activity that has diverse functional roles in the regulation of peptide hormones, neuropeptides, chemokines and growth factors. We recently isolated a novel inhibitor of DPPIV, sulphosti...

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Veröffentlicht in:	Journal of antibiotics 2005-02, Vol.58 (2), p.111-117
Hauptverfasser:	Abe, Masatoshi, Abe, Fuminori, Nishimura, Chihiro, Ichimura, Eiji, Ogasawara, Asuka, Ichinei, Megumi, Muraoka, Yasuhiko, Saino, Tetsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating Agents Animals Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Bone marrow Bone Marrow Cells - drug effects Cyclophosphamide Cytokines - biosynthesis Dipeptidyl Peptidase 4 - drug effects Enzyme-Linked Immunosorbent Assay Granulocyte Colony-Stimulating Factor - biosynthesis Growth factors Hematopoiesis - drug effects Hormones Leukocyte Count Leukopenia - chemically induced Leukopenia - drug therapy Leukopenia - pathology Life Sciences Male Medicinal Chemistry Mice Mice, Inbred ICR Microbiology Neutrophils - drug effects Organic Chemistry Organophosphorus Compounds - pharmacology original-article Piperidones - pharmacology Protease Inhibitors - pharmacology Stimulation, Chemical Streptomyces
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