Genetically Manipulated Bacterial Toxin as a New Generation Mucosal Adjuvant

Cholera toxin (CT) and heat‐labile toxin (LT) of Escherichia coli act as adjuvants for the enhancement of mucosal and serum antibody (Ab) responses to mucosally co‐administered protein antigen (Ag). Both LT and CT induce B7‐2 expression on antigen‐presenting cells (APCs) for subsequent co‐stimulator...

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Veröffentlicht in:	Scandinavian journal of immunology 2001-03, Vol.53 (3), p.211-217
Hauptverfasser:	Yamamoto, M., Mcghee, J. R., Hagiwara, Y., Otake, S., Kiyono, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - genetics Adjuvants, Immunologic - pharmacology Animals Antigen-Presenting Cells - drug effects Antigen-Presenting Cells - immunology Antigens, CD - metabolism B7-2 Antigen Bacterial Toxins - genetics Bacterial Toxins - pharmacology CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology Cholera Toxin - genetics Cholera Toxin - pharmacology Enterotoxins - genetics Enterotoxins - pharmacology Escherichia coli Escherichia coli Proteins Genetic Engineering Humans Immunity, Mucosal - drug effects Interleukin-4 - pharmacology Membrane Glycoproteins - metabolism Mice Mutation
Online-Zugang:	Volltext
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