Induction of BIM, a Proapoptotic BH3-Only BCL-2 Family Member, Is Critical for Neuronal Apoptosis

Sympathetic neuronal death induced by nerve growth factor (NGF) deprivation requires the macromolecular synthesis–dependent translocation of BAX from the cytosol to mitochondria and its subsequent integration into the mitochondrial outer membrane, followed by BAX-mediated cytochrome c (cyt c) releas...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2001-03, Vol.29 (3), p.615-628
Hauptverfasser:	Putcha, Girish V, Moulder, Krista L, Golden, Judith P, Bouillet, Philippe, Adams, Jerry A, Strasser, Andreas, Johnson, Eugene M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Animals Animals, Newborn Apoptosis - physiology Apoptosis Regulatory Proteins bcl-2-Associated X Protein Bcl-2-Like Protein 11 BIM protein Carrier Proteins - biosynthesis Carrier Proteins - genetics Carrier Proteins - physiology Caspases - metabolism Cells, Cultured Cycloheximide - pharmacology Cytochrome c Group - metabolism Cytosol - metabolism Dactinomycin - pharmacology Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Intracellular Membranes - metabolism JNK Mitogen-Activated Protein Kinases MAP Kinase Kinase 4 Membrane Proteins Mice Mitochondria - metabolism Mitochondria - ultrastructure Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - physiology Mutagenesis Nerve Growth Factor - administration & dosage Nerve Growth Factor - physiology Neurons - physiology Neurons - ultrastructure Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - physiology Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Proto-Oncogene Proteins c-bcl-2 - physiology Rats Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis
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