Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and γ radiation

Ku protein is a heterodimer (Ku70 and Ku86) known to play an important role in V(D)J recombination, apoptosis, telomere fusion, and double-strand break repair. Its role in double-strand breaks is relevant to cancer therapy because lack of Ku86 causes one of the most radiation-responsive phenotypes (...

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Veröffentlicht in:	Molecular cancer therapeutics 2005-04, Vol.4 (4), p.529-536
Hauptverfasser:	Ayene, Iraimoudi S, Ford, Lance P, Koch, Cameron J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Nuclear - genetics Antigens, Nuclear - metabolism Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Blotting, Western Cell Line, Tumor Cricetinae Dimerization DNA Damage DNA Repair DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Dose-Response Relationship, Radiation Etoposide - pharmacology Gamma Rays HeLa Cells Humans Ku Autoantigen Microscopy, Fluorescence Molecular targets of radiation response Neoplasms - therapy Phenotype RNA, Messenger - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Silencing and reactivation of gene expression Telomere - ultrastructure Time Factors Topoisomerase II Inhibitors Transfection VDJ Recombinases - metabolism
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