Expression of tissue factor in canine mammary tumours and correlation with grade, stage and markers of haemostasis and inflammation
Tissue factor (TF) expression in human cancers has been associated with a procoagulant state and facilitation of metastasis. This study was conducted in order to evaluate if TF was expressed in canine mammary tumours. Forty epithelial mammary tumours from 28 dogs were included. TF expression of the...
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| Veröffentlicht in: | Veterinary & comparative oncology 2016-06, Vol.14 (2), p.191-201 |
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| creator | Andreasen, E. B. Nielsen, O. L. Tranholm, M. Knudsen, T. Kristensen, A. T. |
| description | Tissue factor (TF) expression in human cancers has been associated with a procoagulant state and facilitation of metastasis. This study was conducted in order to evaluate if TF was expressed in canine mammary tumours. Forty epithelial mammary tumours from 28 dogs were included. TF expression of the tumours was evaluated by immunohistochemistry using a polyclonal antibody against recombinant canine TF. In addition, thromboelastography, haemostatic and inflammatory parameters were evaluated in the patients. TF was recognized in 44% of benign and 58% of malignant tumours. TF localized to the cytoplasmic membrane of neoplastic luminal epithelial cells and/or diffusely in the cytoplasm. No association was found between TF expression and stage or grade of disease. A significant association between TF expression and antithrombin and plasminogen was found, and extensive TF expression was seen in a lymph node metastasis classified as anaplastic mammary carcinoma from a dog with concomitant disseminated intravascular coagulation (DIC). |
| doi_str_mv | 10.1111/vco.12089 |
| format | Article |
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B. ; Nielsen, O. L. ; Tranholm, M. ; Knudsen, T. ; Kristensen, A. T.</creator><creatorcontrib>Andreasen, E. B. ; Nielsen, O. L. ; Tranholm, M. ; Knudsen, T. ; Kristensen, A. T.</creatorcontrib><description>Tissue factor (TF) expression in human cancers has been associated with a procoagulant state and facilitation of metastasis. This study was conducted in order to evaluate if TF was expressed in canine mammary tumours. Forty epithelial mammary tumours from 28 dogs were included. TF expression of the tumours was evaluated by immunohistochemistry using a polyclonal antibody against recombinant canine TF. In addition, thromboelastography, haemostatic and inflammatory parameters were evaluated in the patients. TF was recognized in 44% of benign and 58% of malignant tumours. TF localized to the cytoplasmic membrane of neoplastic luminal epithelial cells and/or diffusely in the cytoplasm. No association was found between TF expression and stage or grade of disease. 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B.</creatorcontrib><creatorcontrib>Nielsen, O. L.</creatorcontrib><creatorcontrib>Tranholm, M.</creatorcontrib><creatorcontrib>Knudsen, T.</creatorcontrib><creatorcontrib>Kristensen, A. T.</creatorcontrib><title>Expression of tissue factor in canine mammary tumours and correlation with grade, stage and markers of haemostasis and inflammation</title><title>Veterinary & comparative oncology</title><addtitle>Vet Comp Oncol</addtitle><description>Tissue factor (TF) expression in human cancers has been associated with a procoagulant state and facilitation of metastasis. This study was conducted in order to evaluate if TF was expressed in canine mammary tumours. Forty epithelial mammary tumours from 28 dogs were included. TF expression of the tumours was evaluated by immunohistochemistry using a polyclonal antibody against recombinant canine TF. In addition, thromboelastography, haemostatic and inflammatory parameters were evaluated in the patients. TF was recognized in 44% of benign and 58% of malignant tumours. TF localized to the cytoplasmic membrane of neoplastic luminal epithelial cells and/or diffusely in the cytoplasm. No association was found between TF expression and stage or grade of disease. A significant association between TF expression and antithrombin and plasminogen was found, and extensive TF expression was seen in a lymph node metastasis classified as anaplastic mammary carcinoma from a dog with concomitant disseminated intravascular coagulation (DIC).</description><subject>Adenoma - metabolism</subject><subject>Adenoma - veterinary</subject><subject>Animals</subject><subject>Antithrombins - metabolism</subject><subject>Biomarkers, Tumor</subject><subject>Blood Coagulation</subject><subject>Carcinoma - metabolism</subject><subject>Carcinoma - veterinary</subject><subject>dog</subject><subject>Dog Diseases - genetics</subject><subject>Dog Diseases - metabolism</subject><subject>Dogs</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic - physiology</subject><subject>haemostasis</subject><subject>Inflammation - metabolism</subject><subject>Mammary Neoplasms, Animal - metabolism</subject><subject>Mammary Neoplasms, Animal - pathology</subject><subject>mammary tumour</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Staging</subject><subject>Plasminogen - metabolism</subject><subject>Thromboplastin - genetics</subject><subject>Thromboplastin - metabolism</subject><subject>tissue factor</subject><issn>1476-5810</issn><issn>1476-5829</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtO3DAYRq2KqlzaRV-g8hIkAnbsxPGyGnEpRcCiUNSN5bH_gNskHuwEZtZ9cRwCs8MbW_I5Z_Eh9JWSA5rO4aPxBzQnlfyAtigXZVZUudxYvynZRNsx_iUkzznLP6HNnJeCl7TaQv-PlosAMTrfYV_j3sU4AK616X3ArsNGd64D3Oq21WGF-6H1Q4hYdxYbHwI0uh_VJ9ff47ugLezj2Os7eCGS8g8SncL3GlqffqKbZNfVzdgc7c_oY62bCF9e7x10fXz0a3aanV-e_Jh9P88MK5nM5qQuDC21sJzJWjNBzZxJQgmRwgphoZ6LorBgJSlMyWihLTeSV5JwUlVEsx20O3UXwT8MEHvVumigaXQHfoiKikqkFqtoQvcm1AQfY4BaLYIbF1CUqHFzlTZXL5sn9ttrdpi3YNfk28gJOJyAJ9fA6v2SupldviWzyXCxh-XaSHOqUjBRqN8XJ-r49urn2R9-qy7YM9PKnLM</recordid><startdate>201606</startdate><enddate>201606</enddate><creator>Andreasen, E. 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B.</creatorcontrib><creatorcontrib>Nielsen, O. L.</creatorcontrib><creatorcontrib>Tranholm, M.</creatorcontrib><creatorcontrib>Knudsen, T.</creatorcontrib><creatorcontrib>Kristensen, A. T.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary & comparative oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andreasen, E. B.</au><au>Nielsen, O. L.</au><au>Tranholm, M.</au><au>Knudsen, T.</au><au>Kristensen, A. T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of tissue factor in canine mammary tumours and correlation with grade, stage and markers of haemostasis and inflammation</atitle><jtitle>Veterinary & comparative oncology</jtitle><addtitle>Vet Comp Oncol</addtitle><date>2016-06</date><risdate>2016</risdate><volume>14</volume><issue>2</issue><spage>191</spage><epage>201</epage><pages>191-201</pages><issn>1476-5810</issn><eissn>1476-5829</eissn><abstract>Tissue factor (TF) expression in human cancers has been associated with a procoagulant state and facilitation of metastasis. This study was conducted in order to evaluate if TF was expressed in canine mammary tumours. Forty epithelial mammary tumours from 28 dogs were included. TF expression of the tumours was evaluated by immunohistochemistry using a polyclonal antibody against recombinant canine TF. In addition, thromboelastography, haemostatic and inflammatory parameters were evaluated in the patients. TF was recognized in 44% of benign and 58% of malignant tumours. TF localized to the cytoplasmic membrane of neoplastic luminal epithelial cells and/or diffusely in the cytoplasm. No association was found between TF expression and stage or grade of disease. A significant association between TF expression and antithrombin and plasminogen was found, and extensive TF expression was seen in a lymph node metastasis classified as anaplastic mammary carcinoma from a dog with concomitant disseminated intravascular coagulation (DIC).</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>24674618</pmid><doi>10.1111/vco.12089</doi><tpages>11</tpages></addata></record> |
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| subjects | Adenoma - metabolism Adenoma - veterinary Animals Antithrombins - metabolism Biomarkers, Tumor Blood Coagulation Carcinoma - metabolism Carcinoma - veterinary dog Dog Diseases - genetics Dog Diseases - metabolism Dogs Female Gene Expression Regulation, Neoplastic - physiology haemostasis Inflammation - metabolism Mammary Neoplasms, Animal - metabolism Mammary Neoplasms, Animal - pathology mammary tumour Neoplasm Grading Neoplasm Staging Plasminogen - metabolism Thromboplastin - genetics Thromboplastin - metabolism tissue factor |
| title | Expression of tissue factor in canine mammary tumours and correlation with grade, stage and markers of haemostasis and inflammation |
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