Vitamin D pathway gene polymorphisms as predictors of hepatitis C virus-related mixed cryoglobulinemia
Mixed cryoglobulinemia (MC) is the most frequent extrahepatic hepatitis C virus (HCV) complication. Vitamin D is a modulator of several biological processes, including immune and skeletal systems and MC presence and systemic vasculitis were associated independently with low levels of vitamin D. Cons...
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| Veröffentlicht in: | Pharmacogenetics and genomics 2016-06, Vol.26 (6), p.307-310 |
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| creator | Cusato, Jessica Boglione, Lucio De Nicolò, Amedeo Cardellino, Chiara Simona Carcieri, Chiara Cariti, Giuseppe Di Perri, Giovanni D'Avolio, Antonio |
| description | Mixed cryoglobulinemia (MC) is the most frequent extrahepatic hepatitis C virus (HCV) complication. Vitamin D is a modulator of several biological processes, including immune and skeletal systems and MC presence and systemic vasculitis were associated independently with low levels of vitamin D. Considering the impact of vitamin D, we aimed to evaluate the role of some single nucleotide polymorphisms (SNPs) of vitamin D pathway genes in the prediction of MC in HCV patients treated with pegylated interferon and ribavirin. We investigated SNPs in IL-28B, CYP27B1, CYP27A1, CYP24A1, VDBP, and VDR genes through real-time PCR. VDR gene SNPs were related to baseline viral load: VDR BsmI AA (P=0.018), TaqI CC (P=0.009), and ApaI AA (P=0.004) showed a lower baseline HCV count. Among vitamin D pathway gene polymorphisms, VDR FokI T>C was a factor associated with the presence of MC in the study population (P=0.011): related to C allele carriers (TT vs. TC/CC), we obtained a P-value of 0.003. In the logistic regression analysis to assess which demographic, clinical, or genetic factors could predict the presence of cryoglobulin, the TT/CC IL-28B rs8099917/rs12979860 haplotype [P |
| doi_str_mv | 10.1097/FPC.0000000000000223 |
| format | Article |
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Vitamin D is a modulator of several biological processes, including immune and skeletal systems and MC presence and systemic vasculitis were associated independently with low levels of vitamin D. Considering the impact of vitamin D, we aimed to evaluate the role of some single nucleotide polymorphisms (SNPs) of vitamin D pathway genes in the prediction of MC in HCV patients treated with pegylated interferon and ribavirin. We investigated SNPs in IL-28B, CYP27B1, CYP27A1, CYP24A1, VDBP, and VDR genes through real-time PCR. VDR gene SNPs were related to baseline viral load: VDR BsmI AA (P=0.018), TaqI CC (P=0.009), and ApaI AA (P=0.004) showed a lower baseline HCV count. Among vitamin D pathway gene polymorphisms, VDR FokI T>C was a factor associated with the presence of MC in the study population (P=0.011): related to C allele carriers (TT vs. TC/CC), we obtained a P-value of 0.003. In the logistic regression analysis to assess which demographic, clinical, or genetic factors could predict the presence of cryoglobulin, the TT/CC IL-28B rs8099917/rs12979860 haplotype [P<0.001; odds ratio (OR) 3.516 (1.951-6.336)], baseline viral load [P<0.001; OR 1.000 (0.999-1.001)], and VDR FokI TC/CC genotypes [0.044; OR 0.463 (0.218-0.981)] remained in the final regression model. These data could help physicians identify patients with a higher probability of developing MC extrahepatic complications.</description><identifier>ISSN: 1744-6872</identifier><identifier>EISSN: 1744-6880</identifier><identifier>DOI: 10.1097/FPC.0000000000000223</identifier><identifier>PMID: 27139837</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Antiviral Agents - therapeutic use ; Cryoglobulinemia - diagnosis ; Cryoglobulinemia - etiology ; Female ; Genotype ; Haplotypes - genetics ; Hepacivirus - genetics ; Hepacivirus - isolation & purification ; Hepatitis C, Chronic - complications ; Hepatitis C, Chronic - drug therapy ; Hepatitis C, Chronic - genetics ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide - genetics ; Receptors, Calcitriol - genetics ; Retrospective Studies ; Signal Transduction ; Viral Load ; Vitamin D - metabolism</subject><ispartof>Pharmacogenetics and genomics, 2016-06, Vol.26 (6), p.307-310</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c307t-8adad95fb38aaf5c895ff6931e62e44d08377edbd069d0e36161c8df5210d29f3</citedby><cites>FETCH-LOGICAL-c307t-8adad95fb38aaf5c895ff6931e62e44d08377edbd069d0e36161c8df5210d29f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27139837$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cusato, Jessica</creatorcontrib><creatorcontrib>Boglione, Lucio</creatorcontrib><creatorcontrib>De Nicolò, Amedeo</creatorcontrib><creatorcontrib>Cardellino, Chiara Simona</creatorcontrib><creatorcontrib>Carcieri, Chiara</creatorcontrib><creatorcontrib>Cariti, Giuseppe</creatorcontrib><creatorcontrib>Di Perri, Giovanni</creatorcontrib><creatorcontrib>D'Avolio, Antonio</creatorcontrib><title>Vitamin D pathway gene polymorphisms as predictors of hepatitis C virus-related mixed cryoglobulinemia</title><title>Pharmacogenetics and genomics</title><addtitle>Pharmacogenet Genomics</addtitle><description>Mixed cryoglobulinemia (MC) is the most frequent extrahepatic hepatitis C virus (HCV) complication. Vitamin D is a modulator of several biological processes, including immune and skeletal systems and MC presence and systemic vasculitis were associated independently with low levels of vitamin D. Considering the impact of vitamin D, we aimed to evaluate the role of some single nucleotide polymorphisms (SNPs) of vitamin D pathway genes in the prediction of MC in HCV patients treated with pegylated interferon and ribavirin. We investigated SNPs in IL-28B, CYP27B1, CYP27A1, CYP24A1, VDBP, and VDR genes through real-time PCR. VDR gene SNPs were related to baseline viral load: VDR BsmI AA (P=0.018), TaqI CC (P=0.009), and ApaI AA (P=0.004) showed a lower baseline HCV count. Among vitamin D pathway gene polymorphisms, VDR FokI T>C was a factor associated with the presence of MC in the study population (P=0.011): related to C allele carriers (TT vs. TC/CC), we obtained a P-value of 0.003. In the logistic regression analysis to assess which demographic, clinical, or genetic factors could predict the presence of cryoglobulin, the TT/CC IL-28B rs8099917/rs12979860 haplotype [P<0.001; odds ratio (OR) 3.516 (1.951-6.336)], baseline viral load [P<0.001; OR 1.000 (0.999-1.001)], and VDR FokI TC/CC genotypes [0.044; OR 0.463 (0.218-0.981)] remained in the final regression model. These data could help physicians identify patients with a higher probability of developing MC extrahepatic complications.</description><subject>Adult</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Cryoglobulinemia - diagnosis</subject><subject>Cryoglobulinemia - etiology</subject><subject>Female</subject><subject>Genotype</subject><subject>Haplotypes - genetics</subject><subject>Hepacivirus - genetics</subject><subject>Hepacivirus - isolation & purification</subject><subject>Hepatitis C, Chronic - complications</subject><subject>Hepatitis C, Chronic - drug therapy</subject><subject>Hepatitis C, Chronic - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Receptors, Calcitriol - genetics</subject><subject>Retrospective Studies</subject><subject>Signal Transduction</subject><subject>Viral Load</subject><subject>Vitamin D - metabolism</subject><issn>1744-6872</issn><issn>1744-6880</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkDFPwzAQhS0EoqXwDxDyyJJix6kdjyhQQKoEA7BGTnxujZI42AmQf09QS4W44e4N792dPoTOKZlTIsXV8imbk78Vx-wATalIkoinKTncaxFP0EkIb4QwLpP4GE1iQZlMmZgi82o7VdsG3-BWdZtPNeA1NIBbVw218-3GhjpgFXDrQduycz5gZ_AGRrftbMAZ_rC-D5GHSnWgcW2_xl76wa0rV_SVbaC26hQdGVUFONvNGXpZ3j5n99Hq8e4hu15FJSOii1KllZYLU7BUKbMo01EbLhkFHkOSaDL-LEAXmnCpCTBOOS1TbRYxJTqWhs3Q5XZv6917D6HLaxtKqCrVgOtDTkUqiGRcyNGabK2ldyF4MHnrba38kFOS_xDOR8L5f8Jj7GJ3oS9q0PvQL1L2DTxdeHk</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Cusato, Jessica</creator><creator>Boglione, Lucio</creator><creator>De Nicolò, Amedeo</creator><creator>Cardellino, Chiara Simona</creator><creator>Carcieri, Chiara</creator><creator>Cariti, Giuseppe</creator><creator>Di Perri, Giovanni</creator><creator>D'Avolio, Antonio</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160601</creationdate><title>Vitamin D pathway gene polymorphisms as predictors of hepatitis C virus-related mixed cryoglobulinemia</title><author>Cusato, Jessica ; Boglione, Lucio ; De Nicolò, Amedeo ; Cardellino, Chiara Simona ; Carcieri, Chiara ; Cariti, Giuseppe ; Di Perri, Giovanni ; D'Avolio, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-8adad95fb38aaf5c895ff6931e62e44d08377edbd069d0e36161c8df5210d29f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Cryoglobulinemia - diagnosis</topic><topic>Cryoglobulinemia - etiology</topic><topic>Female</topic><topic>Genotype</topic><topic>Haplotypes - genetics</topic><topic>Hepacivirus - genetics</topic><topic>Hepacivirus - isolation & purification</topic><topic>Hepatitis C, Chronic - complications</topic><topic>Hepatitis C, Chronic - drug therapy</topic><topic>Hepatitis C, Chronic - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Receptors, Calcitriol - genetics</topic><topic>Retrospective Studies</topic><topic>Signal Transduction</topic><topic>Viral Load</topic><topic>Vitamin D - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cusato, Jessica</creatorcontrib><creatorcontrib>Boglione, Lucio</creatorcontrib><creatorcontrib>De Nicolò, Amedeo</creatorcontrib><creatorcontrib>Cardellino, Chiara Simona</creatorcontrib><creatorcontrib>Carcieri, Chiara</creatorcontrib><creatorcontrib>Cariti, Giuseppe</creatorcontrib><creatorcontrib>Di Perri, Giovanni</creatorcontrib><creatorcontrib>D'Avolio, Antonio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacogenetics and genomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cusato, Jessica</au><au>Boglione, Lucio</au><au>De Nicolò, Amedeo</au><au>Cardellino, Chiara Simona</au><au>Carcieri, Chiara</au><au>Cariti, Giuseppe</au><au>Di Perri, Giovanni</au><au>D'Avolio, Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D pathway gene polymorphisms as predictors of hepatitis C virus-related mixed cryoglobulinemia</atitle><jtitle>Pharmacogenetics and genomics</jtitle><addtitle>Pharmacogenet Genomics</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>26</volume><issue>6</issue><spage>307</spage><epage>310</epage><pages>307-310</pages><issn>1744-6872</issn><eissn>1744-6880</eissn><abstract>Mixed cryoglobulinemia (MC) is the most frequent extrahepatic hepatitis C virus (HCV) complication. Vitamin D is a modulator of several biological processes, including immune and skeletal systems and MC presence and systemic vasculitis were associated independently with low levels of vitamin D. Considering the impact of vitamin D, we aimed to evaluate the role of some single nucleotide polymorphisms (SNPs) of vitamin D pathway genes in the prediction of MC in HCV patients treated with pegylated interferon and ribavirin. We investigated SNPs in IL-28B, CYP27B1, CYP27A1, CYP24A1, VDBP, and VDR genes through real-time PCR. VDR gene SNPs were related to baseline viral load: VDR BsmI AA (P=0.018), TaqI CC (P=0.009), and ApaI AA (P=0.004) showed a lower baseline HCV count. Among vitamin D pathway gene polymorphisms, VDR FokI T>C was a factor associated with the presence of MC in the study population (P=0.011): related to C allele carriers (TT vs. TC/CC), we obtained a P-value of 0.003. In the logistic regression analysis to assess which demographic, clinical, or genetic factors could predict the presence of cryoglobulin, the TT/CC IL-28B rs8099917/rs12979860 haplotype [P<0.001; odds ratio (OR) 3.516 (1.951-6.336)], baseline viral load [P<0.001; OR 1.000 (0.999-1.001)], and VDR FokI TC/CC genotypes [0.044; OR 0.463 (0.218-0.981)] remained in the final regression model. These data could help physicians identify patients with a higher probability of developing MC extrahepatic complications.</abstract><cop>United States</cop><pmid>27139837</pmid><doi>10.1097/FPC.0000000000000223</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Antiviral Agents - therapeutic use Cryoglobulinemia - diagnosis Cryoglobulinemia - etiology Female Genotype Haplotypes - genetics Hepacivirus - genetics Hepacivirus - isolation & purification Hepatitis C, Chronic - complications Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - genetics Humans Male Middle Aged Polymorphism, Single Nucleotide - genetics Receptors, Calcitriol - genetics Retrospective Studies Signal Transduction Viral Load Vitamin D - metabolism |
| title | Vitamin D pathway gene polymorphisms as predictors of hepatitis C virus-related mixed cryoglobulinemia |
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