Pharmacokinetics and Biodistribution of Aurantiamide and Aurantiamide Acetate in Rats after Oral Administration of Portulaca oleracea L. Extracts
Aurantiamide and aurantiamide acetate are the main active constituents of purslane (Portulaca oleracea L.), an edible plant with various biological activities. In this study, we developed a validated UHPLC-MS/MS method to quantitate the concentrations of aurantiamide and aurantiamide acetate in the...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2016-05, Vol.64 (17), p.3445-3455 |
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| container_issue | 17 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Chen, Lijiang Liu, Yang Jia, Dechao Yang, Jia Zhao, Jinhua Chen, Changlan Liu, Hongsheng Liang, Xiao |
| description | Aurantiamide and aurantiamide acetate are the main active constituents of purslane (Portulaca oleracea L.), an edible plant with various biological activities. In this study, we developed a validated UHPLC-MS/MS method to quantitate the concentrations of aurantiamide and aurantiamide acetate in the plasma and various organ tissues of rat as the basis to study their pharmacological profile and distribution in vivo. Aurantiamide and aurantiamide acetate were rapidly absorbed following oral administration, both achieving a C max at around 0.2 h. The extent of their metabolisms also varied among different organ tissues, resulting in about 90% reduction in concentrations 4 h after their administration, thus leaving no long-term accumulation in the tissues. This is the first study to examine the pharmacokinetic and biodistribution of aurantiamide and aurantiamide acetate in rat, and our work may serve as the first step toward the investigation of the underlying mechanisms associated with the biological activity of purslane. |
| doi_str_mv | 10.1021/acs.jafc.6b00470 |
| format | Article |
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Extracts</title><source>MEDLINE</source><source>American Chemical Society Journals</source><creator>Chen, Lijiang ; Liu, Yang ; Jia, Dechao ; Yang, Jia ; Zhao, Jinhua ; Chen, Changlan ; Liu, Hongsheng ; Liang, Xiao</creator><creatorcontrib>Chen, Lijiang ; Liu, Yang ; Jia, Dechao ; Yang, Jia ; Zhao, Jinhua ; Chen, Changlan ; Liu, Hongsheng ; Liang, Xiao</creatorcontrib><description>Aurantiamide and aurantiamide acetate are the main active constituents of purslane (Portulaca oleracea L.), an edible plant with various biological activities. In this study, we developed a validated UHPLC-MS/MS method to quantitate the concentrations of aurantiamide and aurantiamide acetate in the plasma and various organ tissues of rat as the basis to study their pharmacological profile and distribution in vivo. Aurantiamide and aurantiamide acetate were rapidly absorbed following oral administration, both achieving a C max at around 0.2 h. The extent of their metabolisms also varied among different organ tissues, resulting in about 90% reduction in concentrations 4 h after their administration, thus leaving no long-term accumulation in the tissues. This is the first study to examine the pharmacokinetic and biodistribution of aurantiamide and aurantiamide acetate in rat, and our work may serve as the first step toward the investigation of the underlying mechanisms associated with the biological activity of purslane.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/acs.jafc.6b00470</identifier><identifier>PMID: 27075043</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Administration, Oral ; Animals ; Dipeptides - pharmacokinetics ; Male ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacokinetics ; Portulaca - chemistry ; Rats ; Rats, Sprague-Dawley ; Tissue Distribution</subject><ispartof>Journal of agricultural and food chemistry, 2016-05, Vol.64 (17), p.3445-3455</ispartof><rights>Copyright © 2016 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a336t-a6a8bb0ea400700f54013da80204ad65e3fade0004bd8a4b8cad0dfc2a7e46413</citedby><cites>FETCH-LOGICAL-a336t-a6a8bb0ea400700f54013da80204ad65e3fade0004bd8a4b8cad0dfc2a7e46413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.jafc.6b00470$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.jafc.6b00470$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>315,781,785,2766,27078,27926,27927,56740,56790</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27075043$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Lijiang</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Jia, Dechao</creatorcontrib><creatorcontrib>Yang, Jia</creatorcontrib><creatorcontrib>Zhao, Jinhua</creatorcontrib><creatorcontrib>Chen, Changlan</creatorcontrib><creatorcontrib>Liu, Hongsheng</creatorcontrib><creatorcontrib>Liang, Xiao</creatorcontrib><title>Pharmacokinetics and Biodistribution of Aurantiamide and Aurantiamide Acetate in Rats after Oral Administration of Portulaca oleracea L. Extracts</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>Aurantiamide and aurantiamide acetate are the main active constituents of purslane (Portulaca oleracea L.), an edible plant with various biological activities. In this study, we developed a validated UHPLC-MS/MS method to quantitate the concentrations of aurantiamide and aurantiamide acetate in the plasma and various organ tissues of rat as the basis to study their pharmacological profile and distribution in vivo. Aurantiamide and aurantiamide acetate were rapidly absorbed following oral administration, both achieving a C max at around 0.2 h. The extent of their metabolisms also varied among different organ tissues, resulting in about 90% reduction in concentrations 4 h after their administration, thus leaving no long-term accumulation in the tissues. This is the first study to examine the pharmacokinetic and biodistribution of aurantiamide and aurantiamide acetate in rat, and our work may serve as the first step toward the investigation of the underlying mechanisms associated with the biological activity of purslane.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Dipeptides - pharmacokinetics</subject><subject>Male</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacokinetics</subject><subject>Portulaca - chemistry</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Tissue Distribution</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1LxDAQhoMoun7cPUmOHuw6adMPj-viFywooucyTaYYbRtNUtCf4T82666CB08Dw_M-MPMydihgKiAVp6j89BlbNS0aAFnCBpuIPIUkF6LaZBOITFLlhdhhu94_A0CVl7DNdtISyhxkNmGfd0_oelT2xQwUjPIcB83PjdXGB2eaMRg7cNvy2ehwCAZ7o-mb-bOYKQoYiJuB32OIkjaQ47cOOz7TvRmWMvxR3VkXxg4VctuRQ0XIF1N-8R4RFfw-22qx83Swnnvs8fLiYX6dLG6vbuazRYJZVoQEC6yaBgglQAnQ5hJEprGCFCTqIqesRU3xZNnoCmVTKdSgW5ViSbKQIttjxyvvq7NvI_lQ98Yr6jocyI6-FmVVwlnMy4jCClXOeu-orV-d6dF91ALqZRF1LKJeFlGvi4iRo7V9bHrSv4Gfz0fgZAV8R-3ohnjs_74vptqXHA</recordid><startdate>20160504</startdate><enddate>20160504</enddate><creator>Chen, Lijiang</creator><creator>Liu, Yang</creator><creator>Jia, Dechao</creator><creator>Yang, Jia</creator><creator>Zhao, Jinhua</creator><creator>Chen, Changlan</creator><creator>Liu, Hongsheng</creator><creator>Liang, Xiao</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160504</creationdate><title>Pharmacokinetics and Biodistribution of Aurantiamide and Aurantiamide Acetate in Rats after Oral Administration of Portulaca oleracea L. Extracts</title><author>Chen, Lijiang ; Liu, Yang ; Jia, Dechao ; Yang, Jia ; Zhao, Jinhua ; Chen, Changlan ; Liu, Hongsheng ; Liang, Xiao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a336t-a6a8bb0ea400700f54013da80204ad65e3fade0004bd8a4b8cad0dfc2a7e46413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Dipeptides - pharmacokinetics</topic><topic>Male</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacokinetics</topic><topic>Portulaca - chemistry</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Lijiang</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Jia, Dechao</creatorcontrib><creatorcontrib>Yang, Jia</creatorcontrib><creatorcontrib>Zhao, Jinhua</creatorcontrib><creatorcontrib>Chen, Changlan</creatorcontrib><creatorcontrib>Liu, Hongsheng</creatorcontrib><creatorcontrib>Liang, Xiao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Lijiang</au><au>Liu, Yang</au><au>Jia, Dechao</au><au>Yang, Jia</au><au>Zhao, Jinhua</au><au>Chen, Changlan</au><au>Liu, Hongsheng</au><au>Liang, Xiao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics and Biodistribution of Aurantiamide and Aurantiamide Acetate in Rats after Oral Administration of Portulaca oleracea L. Extracts</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2016-05-04</date><risdate>2016</risdate><volume>64</volume><issue>17</issue><spage>3445</spage><epage>3455</epage><pages>3445-3455</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><abstract>Aurantiamide and aurantiamide acetate are the main active constituents of purslane (Portulaca oleracea L.), an edible plant with various biological activities. In this study, we developed a validated UHPLC-MS/MS method to quantitate the concentrations of aurantiamide and aurantiamide acetate in the plasma and various organ tissues of rat as the basis to study their pharmacological profile and distribution in vivo. Aurantiamide and aurantiamide acetate were rapidly absorbed following oral administration, both achieving a C max at around 0.2 h. The extent of their metabolisms also varied among different organ tissues, resulting in about 90% reduction in concentrations 4 h after their administration, thus leaving no long-term accumulation in the tissues. This is the first study to examine the pharmacokinetic and biodistribution of aurantiamide and aurantiamide acetate in rat, and our work may serve as the first step toward the investigation of the underlying mechanisms associated with the biological activity of purslane.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>27075043</pmid><doi>10.1021/acs.jafc.6b00470</doi><tpages>11</tpages></addata></record> |
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| ispartof | Journal of agricultural and food chemistry, 2016-05, Vol.64 (17), p.3445-3455 |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Administration, Oral Animals Dipeptides - pharmacokinetics Male Plant Extracts - administration & dosage Plant Extracts - pharmacokinetics Portulaca - chemistry Rats Rats, Sprague-Dawley Tissue Distribution |
| title | Pharmacokinetics and Biodistribution of Aurantiamide and Aurantiamide Acetate in Rats after Oral Administration of Portulaca oleracea L. Extracts |
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