The Oncolytic Adenovirus VCN-01 as Therapeutic Approach Against Pediatric Osteosarcoma

Osteosarcoma is the most common malignant bone tumor in children and adolescents. Despite aggressive chemotherapy, more than 30% of patients do not respond and develop bone or lung metastasis. Oncolytic adenoviruses engineered to specifically destroy cancer cells are a feasible option for osteosarco...

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Veröffentlicht in:	Clinical cancer research 2016-05, Vol.22 (9), p.2217-2225
Hauptverfasser:	Martínez-Vélez, Naiara, Xipell, Enric, Vera, Beatriz, Acanda de la Rocha, Arlet, Zalacain, Marta, Marrodán, Lucía, Gonzalez-Huarriz, Marisol, Toledo, Gemma, Cascallo, Manel, Alemany, Ramón, Patiño, Ana, Alonso, Marta M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals Bone Neoplasms - pathology Bone Neoplasms - virology Cell Line Cell Line, Tumor Female Genetic Therapy - methods HEK293 Cells Humans Lung Neoplasms - pathology Lung Neoplasms - virology Mice Mice, Nude Oncolytic Virotherapy - methods Oncolytic Viruses - genetics Osteosarcoma - virology Pediatrics Virus Replication - genetics Xenograft Model Antitumor Assays - methods
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