Bone Morphogenetic Protein Receptor Type 2 Mutation in Pulmonary Arterial Hypertension: A View on the Right Ventricle

BACKGROUND—The effect of a mutation in the bone morphogenetic protein receptor 2 gene (BMPR2) gene on right ventricular (RV) pressure overload in patients with pulmonary arterial hypertension (PAH) is unknown. Therefore, we investigated RV function in PAH-patients with and without BMPR2 mutation by...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2016-05, Vol.133 (18), p.1747-1760
Hauptverfasser:	Van Der Bruggen, Cathelijne E.E, Happé, Chris M, Dorfmuller, Peter, Trip, Pia, Spruijt, Onno A, Rol, Nina, Hoevenaars, Femke P, Houweling, Arjan C, Girerd, Barbara, Marcus, Johannes T, Mercier, Olaf, Humbert, Marc, Handoko, M Louis, Van Der Velden, Jolanda, Noordegraaf, Anton Vonk, Bogaard, Harm Jan, Goumans, Marie-José, de Man, Frances S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Bone Morphogenetic Protein Receptors, Type II - genetics Female Humans Hypertension, Pulmonary - diagnosis Hypertension, Pulmonary - genetics Male Middle Aged Mutation - genetics Retrospective Studies Ventricular Dysfunction, Right - diagnosis Ventricular Dysfunction, Right - genetics Ventricular Function, Right - genetics
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