Prediction of Long-Term Mortality Based on Neutrophil-Lymphocyte Ratio After Percutaneous Coronary Intervention
Abstract Background The preprocedural neutrophil-lymphocyte ratio (NLR) is related to adverse outcomes in patients with coronary artery disease. We hypothesized that high NLR is a predictor of cardiac death after percutaneous coronary intervention (PCI). The objective of this investigation was to as...
Gespeichert in:
| Veröffentlicht in: | The American journal of the medical sciences 2016-05, Vol.351 (5), p.467-472 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 472 |
|---|---|
| container_issue | 5 |
| container_start_page | 467 |
| container_title | The American journal of the medical sciences |
| container_volume | 351 |
| creator | Kim, Sam Cheol, MD, PhD Sun, Kyung-Hoon, MD Choi, Dong-Hyun, MD, PhD Lee, Young-Min, MD Choi, Seo-Won, MD Kang, Seong-Ho, MD, PhD Park, Keun Ho, MD, PhD Song, Heesang, PhD |
| description | Abstract Background The preprocedural neutrophil-lymphocyte ratio (NLR) is related to adverse outcomes in patients with coronary artery disease. We hypothesized that high NLR is a predictor of cardiac death after percutaneous coronary intervention (PCI). The objective of this investigation was to assess the associations of NLR, high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B type natriuretic peptide (NT-proBNP) with the occurrence of cardiac death after PCI. Materials and Methods The NLR, hs-cTnT and NT-proBNP were analyzed in 372 patients who underwent PCI. The primary end point was cardiac death. Results The median NLR was 2.3 (interquartile range: 1.5–4.1). There were 21 cardiac death events during a mean follow-up duration of 25.8 months. With the NLR cutoff level set to 3.3 using the receiver-operating characteristic curve, the sensitivity and specificity for differentiating between the group with cardiac death and the group without cardiac death were 85.7% and 59.3%, respectively. Kaplan-Meier analysis revealed that the higher NLR group (≥3.3) had a significantly higher cardiac death rate than the lower NLR group ( |
| doi_str_mv | 10.1016/j.amjms.2015.12.022 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1787085667</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002962915410419</els_id><sourcerecordid>1787085667</sourcerecordid><originalsourceid>FETCH-LOGICAL-c414t-c0eea2aecc4242dc15e99fb16c6ada1dcb1d2546d1ec911a1ab4e6befd64ba4c3</originalsourceid><addsrcrecordid>eNqFkU9v1DAQxS1ERZfCJ0BCPnJJ8DhOsjmAVFb8qbRARduz5dgT6pDEW9uplG-Pw5YeuHCaw7w3b-Y3hLwClgOD6m2fq7EfQ84ZlDnwnHH-hGygLLYZbxr2lGwYYzxrKt6ckuch9IwB30LxjJzyGgSrmdgQd-nRWB2tm6jr6N5NP7Nr9CP96nxUg40L_aACGpr633CO3h1u7ZDtl_Fw6_QSkf5QyUzPu4ieXqLXc1QTujnQnfNuUn6hF1Pq3eO0hrwgJ50aAr58qGfk5tPH692XbP_988XufJ9pASJmmiEqrlBrwQU3Gkpsmq6FSlfKKDC6BcNLURlA3QAoUK3AqsXOVKJVQhdn5M1x7sG7uxlDlKMNGofhuJyEeluzbVlVdZIWR6n2LgSPnTx4O6bFJTC5kpa9_ENarqQlcJlIJ9frh4C5HdE8ev6iTYJ3RwGmM-8tehm0xUkn3B51lMbZ_wS8_8evBztZrYZfuGDo3eynRFCCDMkgr9Znr7-GUgAT0BS_AYTlqHk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1787085667</pqid></control><display><type>article</type><title>Prediction of Long-Term Mortality Based on Neutrophil-Lymphocyte Ratio After Percutaneous Coronary Intervention</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Kim, Sam Cheol, MD, PhD ; Sun, Kyung-Hoon, MD ; Choi, Dong-Hyun, MD, PhD ; Lee, Young-Min, MD ; Choi, Seo-Won, MD ; Kang, Seong-Ho, MD, PhD ; Park, Keun Ho, MD, PhD ; Song, Heesang, PhD</creator><creatorcontrib>Kim, Sam Cheol, MD, PhD ; Sun, Kyung-Hoon, MD ; Choi, Dong-Hyun, MD, PhD ; Lee, Young-Min, MD ; Choi, Seo-Won, MD ; Kang, Seong-Ho, MD, PhD ; Park, Keun Ho, MD, PhD ; Song, Heesang, PhD</creatorcontrib><description>Abstract Background The preprocedural neutrophil-lymphocyte ratio (NLR) is related to adverse outcomes in patients with coronary artery disease. We hypothesized that high NLR is a predictor of cardiac death after percutaneous coronary intervention (PCI). The objective of this investigation was to assess the associations of NLR, high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B type natriuretic peptide (NT-proBNP) with the occurrence of cardiac death after PCI. Materials and Methods The NLR, hs-cTnT and NT-proBNP were analyzed in 372 patients who underwent PCI. The primary end point was cardiac death. Results The median NLR was 2.3 (interquartile range: 1.5–4.1). There were 21 cardiac death events during a mean follow-up duration of 25.8 months. With the NLR cutoff level set to 3.3 using the receiver-operating characteristic curve, the sensitivity and specificity for differentiating between the group with cardiac death and the group without cardiac death were 85.7% and 59.3%, respectively. Kaplan-Meier analysis revealed that the higher NLR group (≥3.3) had a significantly higher cardiac death rate than the lower NLR group (<3.3) (11.1% versus 1.4%, log-rank: P < 0.0001). This value was more useful in patients with heart failure (NT-proBNP ≥ 300 ng/L) or myocardial injury (hs-cTnT ≥ 100 ng/L). Conclusions The outcomes of the current study demonstrate that high NLR is a predictor of cardiac death after PCI, especially in patients with heart failure or myocardial injury.</description><identifier>ISSN: 0002-9629</identifier><identifier>EISSN: 1538-2990</identifier><identifier>DOI: 10.1016/j.amjms.2015.12.022</identifier><identifier>PMID: 27140704</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Cardiac death ; Death ; Female ; Humans ; Internal Medicine ; Lymphocytes - metabolism ; Male ; Middle Aged ; Natriuretic Peptide, Brain - metabolism ; Neutrophil-lymphocyte ratio ; Neutrophils - metabolism ; NT-proBNP ; Peptide Fragments - metabolism ; Percutaneous coronary intervention ; Percutaneous Coronary Intervention - adverse effects ; Percutaneous Coronary Intervention - mortality ; Republic of Korea - epidemiology ; Troponin T ; Troponin T - metabolism</subject><ispartof>The American journal of the medical sciences, 2016-05, Vol.351 (5), p.467-472</ispartof><rights>Southern Society for Clinical Investigation</rights><rights>2016 Southern Society for Clinical Investigation</rights><rights>Copyright © 2016 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-c0eea2aecc4242dc15e99fb16c6ada1dcb1d2546d1ec911a1ab4e6befd64ba4c3</citedby><cites>FETCH-LOGICAL-c414t-c0eea2aecc4242dc15e99fb16c6ada1dcb1d2546d1ec911a1ab4e6befd64ba4c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27140704$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Sam Cheol, MD, PhD</creatorcontrib><creatorcontrib>Sun, Kyung-Hoon, MD</creatorcontrib><creatorcontrib>Choi, Dong-Hyun, MD, PhD</creatorcontrib><creatorcontrib>Lee, Young-Min, MD</creatorcontrib><creatorcontrib>Choi, Seo-Won, MD</creatorcontrib><creatorcontrib>Kang, Seong-Ho, MD, PhD</creatorcontrib><creatorcontrib>Park, Keun Ho, MD, PhD</creatorcontrib><creatorcontrib>Song, Heesang, PhD</creatorcontrib><title>Prediction of Long-Term Mortality Based on Neutrophil-Lymphocyte Ratio After Percutaneous Coronary Intervention</title><title>The American journal of the medical sciences</title><addtitle>Am J Med Sci</addtitle><description>Abstract Background The preprocedural neutrophil-lymphocyte ratio (NLR) is related to adverse outcomes in patients with coronary artery disease. We hypothesized that high NLR is a predictor of cardiac death after percutaneous coronary intervention (PCI). The objective of this investigation was to assess the associations of NLR, high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B type natriuretic peptide (NT-proBNP) with the occurrence of cardiac death after PCI. Materials and Methods The NLR, hs-cTnT and NT-proBNP were analyzed in 372 patients who underwent PCI. The primary end point was cardiac death. Results The median NLR was 2.3 (interquartile range: 1.5–4.1). There were 21 cardiac death events during a mean follow-up duration of 25.8 months. With the NLR cutoff level set to 3.3 using the receiver-operating characteristic curve, the sensitivity and specificity for differentiating between the group with cardiac death and the group without cardiac death were 85.7% and 59.3%, respectively. Kaplan-Meier analysis revealed that the higher NLR group (≥3.3) had a significantly higher cardiac death rate than the lower NLR group (<3.3) (11.1% versus 1.4%, log-rank: P < 0.0001). This value was more useful in patients with heart failure (NT-proBNP ≥ 300 ng/L) or myocardial injury (hs-cTnT ≥ 100 ng/L). Conclusions The outcomes of the current study demonstrate that high NLR is a predictor of cardiac death after PCI, especially in patients with heart failure or myocardial injury.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cardiac death</subject><subject>Death</subject><subject>Female</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Lymphocytes - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Natriuretic Peptide, Brain - metabolism</subject><subject>Neutrophil-lymphocyte ratio</subject><subject>Neutrophils - metabolism</subject><subject>NT-proBNP</subject><subject>Peptide Fragments - metabolism</subject><subject>Percutaneous coronary intervention</subject><subject>Percutaneous Coronary Intervention - adverse effects</subject><subject>Percutaneous Coronary Intervention - mortality</subject><subject>Republic of Korea - epidemiology</subject><subject>Troponin T</subject><subject>Troponin T - metabolism</subject><issn>0002-9629</issn><issn>1538-2990</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS1ERZfCJ0BCPnJJ8DhOsjmAVFb8qbRARduz5dgT6pDEW9uplG-Pw5YeuHCaw7w3b-Y3hLwClgOD6m2fq7EfQ84ZlDnwnHH-hGygLLYZbxr2lGwYYzxrKt6ckuch9IwB30LxjJzyGgSrmdgQd-nRWB2tm6jr6N5NP7Nr9CP96nxUg40L_aACGpr633CO3h1u7ZDtl_Fw6_QSkf5QyUzPu4ieXqLXc1QTujnQnfNuUn6hF1Pq3eO0hrwgJ50aAr58qGfk5tPH692XbP_988XufJ9pASJmmiEqrlBrwQU3Gkpsmq6FSlfKKDC6BcNLURlA3QAoUK3AqsXOVKJVQhdn5M1x7sG7uxlDlKMNGofhuJyEeluzbVlVdZIWR6n2LgSPnTx4O6bFJTC5kpa9_ENarqQlcJlIJ9frh4C5HdE8ev6iTYJ3RwGmM-8tehm0xUkn3B51lMbZ_wS8_8evBztZrYZfuGDo3eynRFCCDMkgr9Znr7-GUgAT0BS_AYTlqHk</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>Kim, Sam Cheol, MD, PhD</creator><creator>Sun, Kyung-Hoon, MD</creator><creator>Choi, Dong-Hyun, MD, PhD</creator><creator>Lee, Young-Min, MD</creator><creator>Choi, Seo-Won, MD</creator><creator>Kang, Seong-Ho, MD, PhD</creator><creator>Park, Keun Ho, MD, PhD</creator><creator>Song, Heesang, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160501</creationdate><title>Prediction of Long-Term Mortality Based on Neutrophil-Lymphocyte Ratio After Percutaneous Coronary Intervention</title><author>Kim, Sam Cheol, MD, PhD ; Sun, Kyung-Hoon, MD ; Choi, Dong-Hyun, MD, PhD ; Lee, Young-Min, MD ; Choi, Seo-Won, MD ; Kang, Seong-Ho, MD, PhD ; Park, Keun Ho, MD, PhD ; Song, Heesang, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-c0eea2aecc4242dc15e99fb16c6ada1dcb1d2546d1ec911a1ab4e6befd64ba4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cardiac death</topic><topic>Death</topic><topic>Female</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Lymphocytes - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Natriuretic Peptide, Brain - metabolism</topic><topic>Neutrophil-lymphocyte ratio</topic><topic>Neutrophils - metabolism</topic><topic>NT-proBNP</topic><topic>Peptide Fragments - metabolism</topic><topic>Percutaneous coronary intervention</topic><topic>Percutaneous Coronary Intervention - adverse effects</topic><topic>Percutaneous Coronary Intervention - mortality</topic><topic>Republic of Korea - epidemiology</topic><topic>Troponin T</topic><topic>Troponin T - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Sam Cheol, MD, PhD</creatorcontrib><creatorcontrib>Sun, Kyung-Hoon, MD</creatorcontrib><creatorcontrib>Choi, Dong-Hyun, MD, PhD</creatorcontrib><creatorcontrib>Lee, Young-Min, MD</creatorcontrib><creatorcontrib>Choi, Seo-Won, MD</creatorcontrib><creatorcontrib>Kang, Seong-Ho, MD, PhD</creatorcontrib><creatorcontrib>Park, Keun Ho, MD, PhD</creatorcontrib><creatorcontrib>Song, Heesang, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of the medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Sam Cheol, MD, PhD</au><au>Sun, Kyung-Hoon, MD</au><au>Choi, Dong-Hyun, MD, PhD</au><au>Lee, Young-Min, MD</au><au>Choi, Seo-Won, MD</au><au>Kang, Seong-Ho, MD, PhD</au><au>Park, Keun Ho, MD, PhD</au><au>Song, Heesang, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediction of Long-Term Mortality Based on Neutrophil-Lymphocyte Ratio After Percutaneous Coronary Intervention</atitle><jtitle>The American journal of the medical sciences</jtitle><addtitle>Am J Med Sci</addtitle><date>2016-05-01</date><risdate>2016</risdate><volume>351</volume><issue>5</issue><spage>467</spage><epage>472</epage><pages>467-472</pages><issn>0002-9629</issn><eissn>1538-2990</eissn><abstract>Abstract Background The preprocedural neutrophil-lymphocyte ratio (NLR) is related to adverse outcomes in patients with coronary artery disease. We hypothesized that high NLR is a predictor of cardiac death after percutaneous coronary intervention (PCI). The objective of this investigation was to assess the associations of NLR, high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B type natriuretic peptide (NT-proBNP) with the occurrence of cardiac death after PCI. Materials and Methods The NLR, hs-cTnT and NT-proBNP were analyzed in 372 patients who underwent PCI. The primary end point was cardiac death. Results The median NLR was 2.3 (interquartile range: 1.5–4.1). There were 21 cardiac death events during a mean follow-up duration of 25.8 months. With the NLR cutoff level set to 3.3 using the receiver-operating characteristic curve, the sensitivity and specificity for differentiating between the group with cardiac death and the group without cardiac death were 85.7% and 59.3%, respectively. Kaplan-Meier analysis revealed that the higher NLR group (≥3.3) had a significantly higher cardiac death rate than the lower NLR group (<3.3) (11.1% versus 1.4%, log-rank: P < 0.0001). This value was more useful in patients with heart failure (NT-proBNP ≥ 300 ng/L) or myocardial injury (hs-cTnT ≥ 100 ng/L). Conclusions The outcomes of the current study demonstrate that high NLR is a predictor of cardiac death after PCI, especially in patients with heart failure or myocardial injury.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27140704</pmid><doi>10.1016/j.amjms.2015.12.022</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9629 |
| ispartof | The American journal of the medical sciences, 2016-05, Vol.351 (5), p.467-472 |
| issn | 0002-9629 1538-2990 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1787085667 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over Cardiac death Death Female Humans Internal Medicine Lymphocytes - metabolism Male Middle Aged Natriuretic Peptide, Brain - metabolism Neutrophil-lymphocyte ratio Neutrophils - metabolism NT-proBNP Peptide Fragments - metabolism Percutaneous coronary intervention Percutaneous Coronary Intervention - adverse effects Percutaneous Coronary Intervention - mortality Republic of Korea - epidemiology Troponin T Troponin T - metabolism |
| title | Prediction of Long-Term Mortality Based on Neutrophil-Lymphocyte Ratio After Percutaneous Coronary Intervention |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T08%3A33%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prediction%20of%20Long-Term%20Mortality%20Based%20on%20Neutrophil-Lymphocyte%20Ratio%20After%20Percutaneous%20Coronary%20Intervention&rft.jtitle=The%20American%20journal%20of%20the%20medical%20sciences&rft.au=Kim,%20Sam%20Cheol,%20MD,%20PhD&rft.date=2016-05-01&rft.volume=351&rft.issue=5&rft.spage=467&rft.epage=472&rft.pages=467-472&rft.issn=0002-9629&rft.eissn=1538-2990&rft_id=info:doi/10.1016/j.amjms.2015.12.022&rft_dat=%3Cproquest_cross%3E1787085667%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1787085667&rft_id=info:pmid/27140704&rft_els_id=S0002962915410419&rfr_iscdi=true |