Effects of aging on the susceptibility to the toxic effects of cyclosporin A in rats. Changes in liver glutathione and antioxidant enzymes

Free radicals are involved in aging and cyclosporin A-induced toxicity. The age-related changes in the liver oxidative status of glutathione, lipid peroxidation, and the activity of the enzymatic antioxidant defense system, as well as the influence of aging on the susceptibility to the hepatotoxic e...

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Veröffentlicht in:Free radical biology & medicine 2001-04, Vol.30 (8), p.836-845
Hauptverfasser: Palomero, Jesús, Galán, Ana I, Muñoz, Marı́a E, Tuñón, Marı́a J, González-Gallego, Javier, Jiménez, Rafael
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Sprache:eng
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