The influence of oxidative stress on catalase and MnSOD gene transcription in astrocytes

The brain is particularly vulnerable to oxygen free radicals, which have been implicated in the pathology of several neurological disorders. The antioxidant enzyme (AOE) system of the brain may play an important role in the protection against such oxidative stress. We investigated the influence of o...

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Veröffentlicht in:	Brain research 2001-05, Vol.900 (1), p.128-136
Hauptverfasser:	Röhrdanz, Elke, Schmuck, Gabriele, Ohler, Sandra, Kahl, Regine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - drug effects Astrocytes - metabolism Biological and medical sciences Brain - cytology Brain - embryology Catalase Catalase - biosynthesis Catalase - genetics Enzyme Induction - drug effects Fundamental and applied biological sciences. Psychology Genes, Reporter Hydrogen Peroxide - pharmacology Isolated neuron and nerve. Neuroglia Luciferases - biosynthesis Luciferases - genetics MnSOD Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Oxidation-Reduction Oxidative Stress Paraquat - pharmacology Primary rat astrocytes Rats Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - genetics Regulation RNA, Messenger - biosynthesis Superoxide Dismutase - biosynthesis Superoxide Dismutase - genetics Transcription Transcription, Genetic - drug effects Transfection Vertebrates: nervous system and sense organs
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