Role of Mig-6 in hepatic glucose metabolism

Background Mitogen‐inducible gene 6 (Mig‐6) has an important role in the regulation of cholesterol homeostasis and bile acid synthesis. However, the physiological functions of Mig‐6 in the liver remain poorly understood. Methods To investigate Mig‐6 functioning in the liver, we used conditionally ab...

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Veröffentlicht in:	Journal of diabetes 2016-01, Vol.8 (1), p.86-97
Hauptverfasser:	Yoo, Jung-Yoon, Kim, Tae Hoon, Kong, Sieun, Lee, Ju Hee, Choi, Wonseok, Kim, Koon Soon, Kim, Hyun Jin, Jeong, Jae-Wook, Ku, Bon Jeong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Glucose - metabolism Hep G2 Cells Homeostasis Humans Hyperglycemia - metabolism Hyperglycemia - pathology insulin Insulin - metabolism Insulin Receptor Substrate Proteins - genetics Insulin Receptor Substrate Proteins - metabolism Insulin Resistance Integrases - metabolism Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Intracellular Signaling Peptides and Proteins - physiology liver Liver - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Mig-6 Phosphorylation Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Small Interfering - genetics Signal Transduction 肝脏胰岛素葡萄糖代谢
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