Topical permethrin exposure inhibits antibody production and macrophage function in C57B1/6N mice
Permethrin was applied to the shaved dorsal interscapular region of C57B1/6N mice at doses of 0.5, 1.5 or 5.0 mu l/day. These doses corresponded to approximately 22-220 mg/kg/day topical insecticide. Mice were exposed to permethrin in this manner daily for 10 or 30 consecutive days, or every other d...
Gespeichert in:
| Veröffentlicht in: | Food and chemical toxicology 2001-02, Vol.39 (2), p.133-139 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 139 |
|---|---|
| container_issue | 2 |
| container_start_page | 133 |
| container_title | Food and chemical toxicology |
| container_volume | 39 |
| creator | PUNAREEWATTANA, K SMITH, B. J BLAYLOCK, B. L LONGSTRETH, J SNODGRASS, H. L GOGAL, R. M PRATER, R. M HOLLADAY, S. D |
| description | Permethrin was applied to the shaved dorsal interscapular region of C57B1/6N mice at doses of 0.5, 1.5 or 5.0 mu l/day. These doses corresponded to approximately 22-220 mg/kg/day topical insecticide. Mice were exposed to permethrin in this manner daily for 10 or 30 consecutive days, or every other day for 7 or 14 exposures. The splenic macrophage chemiluminescent response was depressed in a dose-dependent manner at 2 and 10 days post-exposure to permethrin. Phagocytic ability of macrophages was not inhibited. Antibody production as shown by plaque-forming cell (PFC) assay decreased significantly after 10 consecutive days of exposure to permethrin. These data indicate that topical permethrin exposure may produce systemic immune effects. |
| doi_str_mv | 10.1016/S0278-6915(00)00116-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pasca</sourceid><recordid>TN_cdi_proquest_miscellaneous_17867767</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17867767</sourcerecordid><originalsourceid>FETCH-LOGICAL-p212t-372edbcdc63013663870d5c09e36aef4430c28b2ccf6f7c46aa715413e92b7c83</originalsourceid><addsrcrecordid>eNo9j0tLxDAUhYMoOI7-BCEgiC7q3Ju0N-1Siy8YdOG4LmmaOpG-TFpw_r2FGVwdOHx8nMPYJcIdAtLqA4RKI8owuQG4BUCkSByxBaZKRiQTPGaLf-SUnYXwDQAKFS2Y3vSDM7rhg_WtHbfeddz-Dn2YvOWu27rSjYHrbnRlX-344PtqMqPru7mreKuN74et_rK8nrp9PwvyRD3git5464w9Zye1boK9OOSSfT49bvKXaP3-_Jrfr6NBoBgjqYStSlMZkoCSSKYKqsRAZiVpW8exBCPSUhhTU61MTForTGKUNhOlMqlcsuu9d974M9kwFq0LxjaN7mw_hQJVSkqRmsGrA6jD_Lz2ujMuFIN3rfa7IpOUCJB_mX1l9A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17867767</pqid></control><display><type>article</type><title>Topical permethrin exposure inhibits antibody production and macrophage function in C57B1/6N mice</title><source>Elsevier ScienceDirect Journals</source><creator>PUNAREEWATTANA, K ; SMITH, B. J ; BLAYLOCK, B. L ; LONGSTRETH, J ; SNODGRASS, H. L ; GOGAL, R. M ; PRATER, R. M ; HOLLADAY, S. D</creator><creatorcontrib>PUNAREEWATTANA, K ; SMITH, B. J ; BLAYLOCK, B. L ; LONGSTRETH, J ; SNODGRASS, H. L ; GOGAL, R. M ; PRATER, R. M ; HOLLADAY, S. D</creatorcontrib><description>Permethrin was applied to the shaved dorsal interscapular region of C57B1/6N mice at doses of 0.5, 1.5 or 5.0 mu l/day. These doses corresponded to approximately 22-220 mg/kg/day topical insecticide. Mice were exposed to permethrin in this manner daily for 10 or 30 consecutive days, or every other day for 7 or 14 exposures. The splenic macrophage chemiluminescent response was depressed in a dose-dependent manner at 2 and 10 days post-exposure to permethrin. Phagocytic ability of macrophages was not inhibited. Antibody production as shown by plaque-forming cell (PFC) assay decreased significantly after 10 consecutive days of exposure to permethrin. These data indicate that topical permethrin exposure may produce systemic immune effects.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/S0278-6915(00)00116-2</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Science</publisher><subject>Biological and medical sciences ; Medical sciences ; Pesticides, fertilizers and other agrochemicals toxicology ; Toxicology</subject><ispartof>Food and chemical toxicology, 2001-02, Vol.39 (2), p.133-139</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=936520$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>PUNAREEWATTANA, K</creatorcontrib><creatorcontrib>SMITH, B. J</creatorcontrib><creatorcontrib>BLAYLOCK, B. L</creatorcontrib><creatorcontrib>LONGSTRETH, J</creatorcontrib><creatorcontrib>SNODGRASS, H. L</creatorcontrib><creatorcontrib>GOGAL, R. M</creatorcontrib><creatorcontrib>PRATER, R. M</creatorcontrib><creatorcontrib>HOLLADAY, S. D</creatorcontrib><title>Topical permethrin exposure inhibits antibody production and macrophage function in C57B1/6N mice</title><title>Food and chemical toxicology</title><description>Permethrin was applied to the shaved dorsal interscapular region of C57B1/6N mice at doses of 0.5, 1.5 or 5.0 mu l/day. These doses corresponded to approximately 22-220 mg/kg/day topical insecticide. Mice were exposed to permethrin in this manner daily for 10 or 30 consecutive days, or every other day for 7 or 14 exposures. The splenic macrophage chemiluminescent response was depressed in a dose-dependent manner at 2 and 10 days post-exposure to permethrin. Phagocytic ability of macrophages was not inhibited. Antibody production as shown by plaque-forming cell (PFC) assay decreased significantly after 10 consecutive days of exposure to permethrin. These data indicate that topical permethrin exposure may produce systemic immune effects.</description><subject>Biological and medical sciences</subject><subject>Medical sciences</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>Toxicology</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNo9j0tLxDAUhYMoOI7-BCEgiC7q3Ju0N-1Siy8YdOG4LmmaOpG-TFpw_r2FGVwdOHx8nMPYJcIdAtLqA4RKI8owuQG4BUCkSByxBaZKRiQTPGaLf-SUnYXwDQAKFS2Y3vSDM7rhg_WtHbfeddz-Dn2YvOWu27rSjYHrbnRlX-344PtqMqPru7mreKuN74et_rK8nrp9PwvyRD3git5464w9Zye1boK9OOSSfT49bvKXaP3-_Jrfr6NBoBgjqYStSlMZkoCSSKYKqsRAZiVpW8exBCPSUhhTU61MTForTGKUNhOlMqlcsuu9d974M9kwFq0LxjaN7mw_hQJVSkqRmsGrA6jD_Lz2ujMuFIN3rfa7IpOUCJB_mX1l9A</recordid><startdate>20010201</startdate><enddate>20010201</enddate><creator>PUNAREEWATTANA, K</creator><creator>SMITH, B. J</creator><creator>BLAYLOCK, B. L</creator><creator>LONGSTRETH, J</creator><creator>SNODGRASS, H. L</creator><creator>GOGAL, R. M</creator><creator>PRATER, R. M</creator><creator>HOLLADAY, S. D</creator><general>Elsevier Science</general><scope>IQODW</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20010201</creationdate><title>Topical permethrin exposure inhibits antibody production and macrophage function in C57B1/6N mice</title><author>PUNAREEWATTANA, K ; SMITH, B. J ; BLAYLOCK, B. L ; LONGSTRETH, J ; SNODGRASS, H. L ; GOGAL, R. M ; PRATER, R. M ; HOLLADAY, S. D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p212t-372edbcdc63013663870d5c09e36aef4430c28b2ccf6f7c46aa715413e92b7c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological and medical sciences</topic><topic>Medical sciences</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PUNAREEWATTANA, K</creatorcontrib><creatorcontrib>SMITH, B. J</creatorcontrib><creatorcontrib>BLAYLOCK, B. L</creatorcontrib><creatorcontrib>LONGSTRETH, J</creatorcontrib><creatorcontrib>SNODGRASS, H. L</creatorcontrib><creatorcontrib>GOGAL, R. M</creatorcontrib><creatorcontrib>PRATER, R. M</creatorcontrib><creatorcontrib>HOLLADAY, S. D</creatorcontrib><collection>Pascal-Francis</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PUNAREEWATTANA, K</au><au>SMITH, B. J</au><au>BLAYLOCK, B. L</au><au>LONGSTRETH, J</au><au>SNODGRASS, H. L</au><au>GOGAL, R. M</au><au>PRATER, R. M</au><au>HOLLADAY, S. D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Topical permethrin exposure inhibits antibody production and macrophage function in C57B1/6N mice</atitle><jtitle>Food and chemical toxicology</jtitle><date>2001-02-01</date><risdate>2001</risdate><volume>39</volume><issue>2</issue><spage>133</spage><epage>139</epage><pages>133-139</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>Permethrin was applied to the shaved dorsal interscapular region of C57B1/6N mice at doses of 0.5, 1.5 or 5.0 mu l/day. These doses corresponded to approximately 22-220 mg/kg/day topical insecticide. Mice were exposed to permethrin in this manner daily for 10 or 30 consecutive days, or every other day for 7 or 14 exposures. The splenic macrophage chemiluminescent response was depressed in a dose-dependent manner at 2 and 10 days post-exposure to permethrin. Phagocytic ability of macrophages was not inhibited. Antibody production as shown by plaque-forming cell (PFC) assay decreased significantly after 10 consecutive days of exposure to permethrin. These data indicate that topical permethrin exposure may produce systemic immune effects.</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier Science</pub><doi>10.1016/S0278-6915(00)00116-2</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0278-6915 |
| ispartof | Food and chemical toxicology, 2001-02, Vol.39 (2), p.133-139 |
| issn | 0278-6915 1873-6351 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17867767 |
| source | Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Medical sciences Pesticides, fertilizers and other agrochemicals toxicology Toxicology |
| title | Topical permethrin exposure inhibits antibody production and macrophage function in C57B1/6N mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T15%3A32%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Topical%20permethrin%20exposure%20inhibits%20antibody%20production%20and%20macrophage%20function%20in%20C57B1/6N%20mice&rft.jtitle=Food%20and%20chemical%20toxicology&rft.au=PUNAREEWATTANA,%20K&rft.date=2001-02-01&rft.volume=39&rft.issue=2&rft.spage=133&rft.epage=139&rft.pages=133-139&rft.issn=0278-6915&rft.eissn=1873-6351&rft.coden=FCTOD7&rft_id=info:doi/10.1016/S0278-6915(00)00116-2&rft_dat=%3Cproquest_pasca%3E17867767%3C/proquest_pasca%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17867767&rft_id=info:pmid/&rfr_iscdi=true |