Extracellular norepinephrine in the medial hypothalamus increases during feeding in chicks: a microdialysis study
Norepinephrinergic function in the medial hypothalamus is important for the regulation of feeding behavior in chicks as well as in rats. This study was conducted to clarify the variation of extracellular norepinephrine (NE) in the medial hypothalamus, including the paraventricular nucleus (PVN) and...
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| Veröffentlicht in: | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Molecular & integrative physiology, 2000-11, Vol.127 (3), p.331-338 |
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| container_title | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology |
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| creator | Tachibana, Tetsuya Utimura, Daisuke Kato, Hisanori Kubo, Tatsuo Sugahara, Kunio |
| description | Norepinephrinergic function in the medial hypothalamus is important for the regulation of feeding behavior in chicks as well as in rats. This study was conducted to clarify the variation of extracellular norepinephrine (NE) in the medial hypothalamus, including the paraventricular nucleus (PVN) and the ventromedial hypothalamic nucleus (VMN), during feeding behavior of layer-type chicks. To measure extracellular NE and 4-hydroxy-3-methoxyphenylglycol (MHPG), a major metabolite of NE, we used microdialysis and high-pressure liquid chromatography (HPLC) with electrochemical detection. After the collection of baseline samples, food-deprived animals were allowed access to the food for 3 h. Extracellular NE significantly increased during the first hour of access to food, and then returned to baseline levels. MHPG also increased during the feeding, but its increase continued throughout the remainder of the experiment. This study suggests that the variation of NE in the medial hypothalamus may be involved in the control of feeding in layer-type chicks. |
| doi_str_mv | 10.1016/S1095-6433(00)00261-0 |
| format | Article |
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This study was conducted to clarify the variation of extracellular norepinephrine (NE) in the medial hypothalamus, including the paraventricular nucleus (PVN) and the ventromedial hypothalamic nucleus (VMN), during feeding behavior of layer-type chicks. To measure extracellular NE and 4-hydroxy-3-methoxyphenylglycol (MHPG), a major metabolite of NE, we used microdialysis and high-pressure liquid chromatography (HPLC) with electrochemical detection. After the collection of baseline samples, food-deprived animals were allowed access to the food for 3 h. Extracellular NE significantly increased during the first hour of access to food, and then returned to baseline levels. MHPG also increased during the feeding, but its increase continued throughout the remainder of the experiment. This study suggests that the variation of NE in the medial hypothalamus may be involved in the control of feeding in layer-type chicks.</description><identifier>ISSN: 1095-6433</identifier><identifier>EISSN: 1531-4332</identifier><identifier>DOI: 10.1016/S1095-6433(00)00261-0</identifier><identifier>PMID: 11118942</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Chick ; Chickens - metabolism ; Chromatography, High Pressure Liquid ; Electrochemistry ; Extracellular Space - metabolism ; Feeding ; Hypothalamus ; Hypothalamus, Middle - drug effects ; Hypothalamus, Middle - metabolism ; Methoxyhydroxyphenylglycol - metabolism ; Microdialysis ; Norepinephrine ; Norepinephrine - metabolism ; Potassium - pharmacology ; Tetrodotoxin - pharmacology</subject><ispartof>Comparative biochemistry and physiology. 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Part A, Molecular & integrative physiology</title><addtitle>Comp Biochem Physiol A Mol Integr Physiol</addtitle><description>Norepinephrinergic function in the medial hypothalamus is important for the regulation of feeding behavior in chicks as well as in rats. This study was conducted to clarify the variation of extracellular norepinephrine (NE) in the medial hypothalamus, including the paraventricular nucleus (PVN) and the ventromedial hypothalamic nucleus (VMN), during feeding behavior of layer-type chicks. To measure extracellular NE and 4-hydroxy-3-methoxyphenylglycol (MHPG), a major metabolite of NE, we used microdialysis and high-pressure liquid chromatography (HPLC) with electrochemical detection. After the collection of baseline samples, food-deprived animals were allowed access to the food for 3 h. Extracellular NE significantly increased during the first hour of access to food, and then returned to baseline levels. MHPG also increased during the feeding, but its increase continued throughout the remainder of the experiment. This study suggests that the variation of NE in the medial hypothalamus may be involved in the control of feeding in layer-type chicks.</description><subject>Animals</subject><subject>Chick</subject><subject>Chickens - metabolism</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Electrochemistry</subject><subject>Extracellular Space - metabolism</subject><subject>Feeding</subject><subject>Hypothalamus</subject><subject>Hypothalamus, Middle - drug effects</subject><subject>Hypothalamus, Middle - metabolism</subject><subject>Methoxyhydroxyphenylglycol - metabolism</subject><subject>Microdialysis</subject><subject>Norepinephrine</subject><subject>Norepinephrine - metabolism</subject><subject>Potassium - pharmacology</subject><subject>Tetrodotoxin - pharmacology</subject><issn>1095-6433</issn><issn>1531-4332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlOJDEMhiPEiP0RQDkhONSMU0uqigtCiGUkpDkMnKN04lCB2kiqRvTb46YbcRwf4sj5fzv-GDsW8FOAkL_-CqiLROZZdgZwDpBKkcAW2xNFJhKqptt0_5Lssv0YX4AiF_kO2xUUVZ2ne-zt5n0K2mDbzq0OvB8Cjr7HsQl0ct_zqUHeofW65c1yHKZGt7qbIz2ZgDpi5HYm7TN3SCrK5DGNN6_xgmveeROGlXkZfeRxmu3ykP1wuo14tMkH7On25vH6Pnn4c_f7-uohMXlRTUlqXSkgtbqqbAkLKpYuzYTUclHkFTghHErjarCidlhnmTOL2mU6B1lKrW12wE7XfccwvM0YJ9X5uFpU9zjMUYmyklKmkoTFWkhfjTGgU2PwnQ5LJUCtWKtP1moFUgGoT9YKyHeyGTAviNC3awOXBJdrAdKa_zwGFY3H3hCngGZSdvD_GfEBEq2Q0Q</recordid><startdate>20001101</startdate><enddate>20001101</enddate><creator>Tachibana, Tetsuya</creator><creator>Utimura, Daisuke</creator><creator>Kato, Hisanori</creator><creator>Kubo, Tatsuo</creator><creator>Sugahara, Kunio</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope></search><sort><creationdate>20001101</creationdate><title>Extracellular norepinephrine in the medial hypothalamus increases during feeding in chicks: a microdialysis study</title><author>Tachibana, Tetsuya ; Utimura, Daisuke ; Kato, Hisanori ; Kubo, Tatsuo ; Sugahara, Kunio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-2df7102da88d70bc457f2316a6b5480f11fe6cf90d19fe933fcb9f3a40676aad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Chick</topic><topic>Chickens - metabolism</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Electrochemistry</topic><topic>Extracellular Space - metabolism</topic><topic>Feeding</topic><topic>Hypothalamus</topic><topic>Hypothalamus, Middle - drug effects</topic><topic>Hypothalamus, Middle - metabolism</topic><topic>Methoxyhydroxyphenylglycol - metabolism</topic><topic>Microdialysis</topic><topic>Norepinephrine</topic><topic>Norepinephrine - metabolism</topic><topic>Potassium - pharmacology</topic><topic>Tetrodotoxin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tachibana, Tetsuya</creatorcontrib><creatorcontrib>Utimura, Daisuke</creatorcontrib><creatorcontrib>Kato, Hisanori</creatorcontrib><creatorcontrib>Kubo, Tatsuo</creatorcontrib><creatorcontrib>Sugahara, Kunio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><jtitle>Comparative biochemistry and physiology. Part A, Molecular & integrative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tachibana, Tetsuya</au><au>Utimura, Daisuke</au><au>Kato, Hisanori</au><au>Kubo, Tatsuo</au><au>Sugahara, Kunio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extracellular norepinephrine in the medial hypothalamus increases during feeding in chicks: a microdialysis study</atitle><jtitle>Comparative biochemistry and physiology. Part A, Molecular & integrative physiology</jtitle><addtitle>Comp Biochem Physiol A Mol Integr Physiol</addtitle><date>2000-11-01</date><risdate>2000</risdate><volume>127</volume><issue>3</issue><spage>331</spage><epage>338</epage><pages>331-338</pages><issn>1095-6433</issn><eissn>1531-4332</eissn><abstract>Norepinephrinergic function in the medial hypothalamus is important for the regulation of feeding behavior in chicks as well as in rats. This study was conducted to clarify the variation of extracellular norepinephrine (NE) in the medial hypothalamus, including the paraventricular nucleus (PVN) and the ventromedial hypothalamic nucleus (VMN), during feeding behavior of layer-type chicks. To measure extracellular NE and 4-hydroxy-3-methoxyphenylglycol (MHPG), a major metabolite of NE, we used microdialysis and high-pressure liquid chromatography (HPLC) with electrochemical detection. After the collection of baseline samples, food-deprived animals were allowed access to the food for 3 h. Extracellular NE significantly increased during the first hour of access to food, and then returned to baseline levels. MHPG also increased during the feeding, but its increase continued throughout the remainder of the experiment. This study suggests that the variation of NE in the medial hypothalamus may be involved in the control of feeding in layer-type chicks.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11118942</pmid><doi>10.1016/S1095-6433(00)00261-0</doi><tpages>8</tpages></addata></record> |
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| ispartof | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2000-11, Vol.127 (3), p.331-338 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Chick Chickens - metabolism Chromatography, High Pressure Liquid Electrochemistry Extracellular Space - metabolism Feeding Hypothalamus Hypothalamus, Middle - drug effects Hypothalamus, Middle - metabolism Methoxyhydroxyphenylglycol - metabolism Microdialysis Norepinephrine Norepinephrine - metabolism Potassium - pharmacology Tetrodotoxin - pharmacology |
| title | Extracellular norepinephrine in the medial hypothalamus increases during feeding in chicks: a microdialysis study |
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