Reversible reprotoxic effects of manganese through DAF-16 transcription factor activation and vitellogenin downregulation in Caenorhabditis elegans

Vitellogenesis is the yolk production process which provides the essential nutrients for the developing embryos. Yolk is a lipoprotein particle that presents lipids and lipid-binding proteins, referred to as vitellogenins (VIT). The Caenorhabditis elegans nematode has six genes encoding VIT lipoprot...

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Veröffentlicht in:	Life sciences (1973) 2016-04, Vol.151, p.218-223
Hauptverfasser:	Gubert, Priscila, Puntel, Bruna, Lehmen, Tassia, Bornhorst, Julia, Avila, Daiana S., Aschner, Michael, Soares, Felix A.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brood size Caenorhabditis elegans Caenorhabditis elegans - drug effects Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - metabolism DAF-16 transcription factor Down-Regulation - drug effects Forkhead Transcription Factors - metabolism Manganese Manganese - toxicity Ovum - drug effects Vitellogenin Vitellogenins - deficiency Vitellogenins - metabolism
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