Mechanism of Dissolution-Induced Nanoparticle Formation from a Copovidone-Based Amorphous Solid Dispersion

Amorphous solid dispersions (ASDs) have been increasingly used to maximize human exposures from poorly soluble drug candidates. One well-studied advantage of ASDs is the increased amorphous drug solubility compared to crystalline forms. This provides more rapid dissolution rates. An additional advan...

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Veröffentlicht in:	Molecular pharmaceutics 2016-05, Vol.13 (5), p.1467-1481
Hauptverfasser:	Harmon, Paul, Galipeau, Kendra, Xu, Wei, Brown, Chad, Wuelfing, W. Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry, Pharmaceutical - methods Hydrophobic and Hydrophilic Interactions Nanoparticles - chemistry Particle Size Pyrrolidines - chemistry Solubility Solutions - chemistry Surface-Active Agents - chemistry Vinyl Compounds - chemistry
Online-Zugang:	Volltext
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