Promoter methylation of DAP-kinase : association with advanced stage in non-small cell lung cancer

Death associated protein (DAP)-kinase is a 16 kDa calmodulin-dependent serine/threonine kinase that carries a death domain at its C-terminus. DAP-kinase functions as a positive mediator of apoptosis that is induced by interferon-gamma. Recent studies suggest that DAP-kinase is involved in tumor meta...

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Veröffentlicht in:	Oncogene 2001-03, Vol.20 (14), p.1765-1770
Hauptverfasser:	KIM, Duk-Hwan, NELSON, Heather H, WIENCKE, John K, CHRISTIANI, David C, WAIN, John C, MARK, Eugene J, KELSEY, Karl T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Apoptosis Apoptosis Regulatory Proteins Asbestos Biological and medical sciences C-Terminus Calcium-binding protein Calcium-Calmodulin-Dependent Protein Kinases - genetics Calmodulin Carcinogens Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Cell death Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Codon CpG Islands DAP kinase DAP protein death associated protein kinase Death-Associated Protein Kinases DNA Methylation Female Fundamental and applied biological sciences. Psychology Genes, p53 Genes, ras Humans Lung cancer lung carcinoma Lung Neoplasms - enzymology Lung Neoplasms - genetics Lung Neoplasms - pathology Lymph nodes Male Metastases Middle Aged Molecular and cellular biology Mutation Neoplasm Staging Non-small cell lung carcinoma p53 Protein Promoter Regions, Genetic Protein-serine/threonine kinase Small cell lung carcinoma Tobacco Tumors γ-Interferon
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