Inactivation of Notch1 in immature thymocytes does not perturb CD4 or CD8 T cell development

Notch proteins influence cell-fate decisions in many developing systems. Several gain-of-function studies have suggested a critical role for Notch 1 signaling in CD4-CD8 lineage commitment, maturation and survival in the thymus. However, we show here that tissue-specific inactivation of the gene enc...

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Veröffentlicht in:	Nature immunology 2001-03, Vol.2 (3), p.235-241
Hauptverfasser:	Held, Werner, Ioannidis, Vassilios, Wilson, Christopher B, Nicolas, Michael, Bakker, Talitha, Littman, Dan R, Wilson, Anne, Wolfer, Anita, Radtke, Freddy, MacDonald, H. Robson
Format:	Artikel
Sprache:	eng
Schlagworte:	CD4 antigen CD8 antigen Inactivation Notch1 protein Survival
Online-Zugang:	Volltext
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