B-Raf and Ha-ras mutations in chemically induced mouse liver tumors

The mitogen-activated protein kinase signalling pathway is a central regulator of tumor growth, which is constitutively activated in chemically induced mouse liver tumors. In about 30–50% of cases this effect can be related to activation of the Ha-ras gene by point mutations, whereas in the remainin...

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Veröffentlicht in:	Oncogene 2005-02, Vol.24 (7), p.1290-1295
Hauptverfasser:	Jaworski, Maike, Buchmann, Albrecht, Bauer, Peter, Riess, Olaf, Schwarz, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences Cancer Cell Biology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic - genetics Diethylnitrosamine DNA, Neoplasm - genetics Fundamental and applied biological sciences. Psychology Genes Genes, ras - genetics Ha-Ras protein Human Genetics Humans Internal Medicine Kinases Liver Liver cancer Liver Neoplasms, Experimental - chemically induced Liver Neoplasms, Experimental - genetics MAP kinase Medicine Medicine & Public Health Mice - genetics Mice, Inbred C3H Molecular and cellular biology Mutation Oncology Point Mutation - genetics Protein kinase Proteins Proto-Oncogene Proteins B-raf - genetics Raf gene Raf protein Ras protein Rodents Sequence Analysis, DNA short-report Signal transduction Tumors
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