Cadmium adaptation in the lung – a double-edged sword?

This review article discusses the major cellular and molecular responses characterizing pulmonary adaptation to cadmium (Cd) that may ultimately contribute to Cd carcinogenesis. Hallmarks of Cd adaptation include hyperplasia and hypertrophy of type II alveolar epithelial stem cells, an inflammatory...

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Veröffentlicht in:	Toxicology (Amsterdam) 2001-03, Vol.160 (1), p.65-70
Hauptverfasser:	Hart, B.A., Potts, R.J., Watkin, R.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Adaptation, Physiological - physiology Administration, Inhalation Apoptosis Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Cadmium Cadmium - administration & dosage Cadmium - toxicity Carcinogenesis Chemical and industrial products toxicology. Toxic occupational diseases DNA repair DNA Repair - drug effects DNA Repair - physiology Environmental Pollutants - toxicity Glutathione Glutathione - metabolism In Vitro Techniques Lung Medical sciences Metallothionein Metallothionein - metabolism Metals and various inorganic compounds Models, Animal Pulmonary Alveoli - cytology Pulmonary Alveoli - drug effects Pulmonary Alveoli - metabolism Toxicology Up-Regulation
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